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Hooding cobras can get ahead of other snakes in the ability to evoke human fear.
Naturwissenschaften
December 2024
Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic.
Article Synopsis
- Fear of snakes is common among humans and primates, considered an adaptive response to potential dangers like venomous snakes.
- Snakes exhibit defensive behaviors that can heighten fear in their predators, particularly when in threatening postures compared to resting ones.
- Cobras are especially effective at evoking fear in humans due to their distinctive hooding posture, suggesting that this behavior has evolved to trigger a strong fear response in mammals.
A Snake Toxin Derivative for Treatment of Hyponatremia and Polycystic Kidney Diseases.
J Am Soc Nephrol
October 2024
CEA, Département Médicaments et Technologies pour la Santé (DMTS), Université Paris Saclay, SIMoS, Gif-sur-Yvette, France.
CARDIORESPIRATORY EFFECTS OF VATINOXAN IN BLESBOK () IMMOBILIZED WITH THIAFENTANIL-MEDETOMIDINE.
J Zoo Wildl Med
September 2024
Wildlife Pharmaceuticals South Africa (Pty) Ltd, White River 1240, South Africa.
Combinations of a low dose of opioid, such as thiafentanil, and a high dose of medetomidine, are increasingly being used for immobilization of African ungulates. Both drugs can have undesirable cardiorespiratory effects. In this study we assessed whether vatinoxan, a peripherally acting alpha-adrenergic receptor antagonist, can be used to alleviate some of these effects without affecting the immobilization quality.
View Article and Find Full Text PDFAntinociceptive in vivo activity and chemical profiling by UHPLC-MS/MS of stem bark and leaves extracts of Ficus maxima Mill. (Moraceae).
J Ethnopharmacol
January 2025
Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
Ethnopharmacological Relevance: Ficus maxima is a medicinal plant extensively used in traditional medicine by Indigenous peoples across Central and South America. It is a member of the family Moraceae, subgenus Pharmacosycea, employed in treating various conditions, including intestinal parasites, gingivitis, internal inflammations, and snake bites. Despite its significant pharmacological potential, the species remains underrepresented in scientific literature.
View Article and Find Full Text PDFRattlesnake Crotalphine Analgesic Active on Tetrodotoxin-Sensitive Na Current in Mouse Dorsal Root Ganglion Neurons.
Toxins (Basel)
August 2024
Département Médicaments et Technologies pour la Santé (DMTS), Institut des Sciences du Vivant Frédéric Joliot, Université Paris-Saclay, CEA, Service d'Ingénierie Moléculaire pour la Santé (SIMoS), EMR CNRS/CEA 9004, F-91191 Gif-sur-Yvette, France.
Article Synopsis
- - Crotalphine, an analgesic peptide from South American rattlesnake venom, has a well-known pain-relieving effect, but its exact working mechanisms remain unclear.
- - Research focused on how crotalphine affects the Na1.7 channel, a target involved in pain sensation, using adult mouse neurons and various assays to assess effects on ion currents and cell viability.
- - Findings revealed that crotalphine can significantly inhibit Na current and impact cell viability, suggesting it may contribute to pain relief through the Na1.7 channel while also causing some cellular damage at higher concentrations.
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