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Highlighting chromosomal rearrangements of five species of Galliformes (Domestic fowl, Common and Japanese quail, Barbary and Chukar partridge) and the Houbara bustard, an endangered Otidiformes: banding cytogenetic is a powerful tool.
Comp Cytogenet
December 2024
Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB), Laboratory of Cellular and Molecular Biology, Team of Developmental Genetics. PO box 32 El-Alia, Bab-Ezzouar, 16110, Algiers, Algeria University of Sciences and Technology Houari Boumediene (USTHB) Algiers Algeria.
Birds are one of the most diverse groups among terrestrial vertebrates. They evolved from theropod dinosaurs, are closely related to the sauropsid group and separated from crocodiles about 240 million years ago. According to the IUCN, 12% of bird populations are threatened with potential extinction.
View Article and Find Full Text PDFIdentification of SNPs and INDELS associated with duck egg quality traits through a genome-wide association analysis.
Poult Sci
December 2024
College of Life Science, Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Fujian Provincial Universities Key Laboratory of Preventive Veterinary Medicine and Biotechnology (Longyan University), Longyan University, Longyan, Fujian, 364012, PR China. Electronic address:
Egg quality traits are economically important in the poultry industry. To explore the genetic architecture and identify potential candidate genes, a genome-wide association study (GWAS) was performed for 13 egg quality traits using data from whole-genome sequencing of 299 Longyan Shan-ma female ducks, including 12 quantitative traits and one qualitative trait, eggshell color (ESC; white, light green, green). From estimation of pedigree genetic parameters, heritability (h) ranged from 0.
View Article and Find Full Text PDFAssessment of cardiac and skeletal muscle metabolites using H-MRS and chemical-shift encoded magnetic resonance imaging: Impact of diabetes, RAGE, and DIAPH1.
NMR Biomed
January 2025
Department of Radiology, Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Diabetes affects metabolism and metabolite concentrations in multiple organs. Previous preclinical studies have shown that receptor for advanced glycation end products (RAGE, gene symbol Ager) and its cytoplasmic domain binding partner, Diaphanous-1 (DIAPH1), are key mediators of diabetic micro- and macro-vascular complications. In this study, we used H-Magnetic Resonance Spectroscopy (MRS) and chemical shift encoded (CSE) Magnetic Resonance Imaging (MRI) to investigate the metabolite and water-fat fraction in the heart and hind limb muscle in a murine model of type 1 diabetes (T1D) and to determine if the metabolite changes in the heart and hind limb are influenced by (a) deletion of Ager or Diaph1 and (b) pharmacological blockade of RAGE-DIAPH1 interaction in mice.
View Article and Find Full Text PDFAlgorithm for forming hospital care episodes by combining attendance contacts in the Danish National Patient Register: A methodological consensus-driven study.
Scand J Public Health
October 2024
Department of Data, Biostatistics and Pharmacoepidemiology, Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Background: Studying complete hospital care episodes from register data, for instance when assessing length of stay, discharges and readmissions, can cause methodological difficulties due to the lack of a contact linkage identifier. We aimed to develop an algorithm combining sequential attendance contacts in the Danish National Patient Register (DNPR) into hospital care episodes, spanning the entire duration and all contacts from hospital arrival to departure.
Methods: The algorithm was developed under the consensus of experts from research institutions across Denmark.
Epigenetic mechanisms in cardiovascular complications of diabetes: towards future therapies.
Mol Med
September 2024
Unit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino IRCCS, Via C. Parea 4, Milano, 20138, Italy.
Article Synopsis
- There is a significant gap in effective prevention and treatment methods for cardiovascular disease and microvascular complications caused by diabetes, despite extensive research on the underlying mechanisms.
- Recent studies suggest that epigenetic factors, like DNA methylation and histone modifications, may contribute to the development of these complications and can potentially be targeted for therapeutic purposes.
- This review highlights the links between diabetes and cardiovascular issues while discussing promising epigenetic drugs (or "epidrugs") that, although still in developmental stages, could offer new treatment options in the future.
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