Four New Depsides Isolated from and Their Significant Nerve-Protective Activities.

By investigating of the roots of , which is one of the most widely used Chinese herbs, we used phytochemical methods successfully to obtain twelve depsides: four depsides (⁻) that were previously undescribed, along with eight known ones (⁻). Their structure characteristics were assessed by HR-ESIMS, CD, NMR (¹H, C, HSQC, HMBC) data analyses. These four newly isolated compounds (⁻), as well as the other eight compounds (⁻), show extraordinary protective effects on hydrogen peroxide-induced apoptosis in HS-SY5Y cells. Among them, depside and depside displayed more obviously protective effects than others.