The aim of this study was to evaluate the reproducibility of the heart rate variability threshold (HRVT) by different HRV indexes and determination criteria. 68 untrained participants, 17 women (24.09±4.91 years old; 21.54±1.97 kg∙m) and 51 men (24.52±3.52 years old; 26.51±6.31 kg∙m), were evaluated on 2 different days (test and retest). The HRVT was determined during an incremental exercise test using 2 indexes (SD1 and RMSSD) and criteria (HRTV first intensity of physical effort with index<3 ms, and HRVT first intensity of physical effort, in which the index presents a difference<1 ms between 2 consecutive intensities). There was no significant difference (<0.05) between the test and retest for any of the variables evaluated. All variables, except for the rate of perceived exertion at HRVT presented moderate to high intraclass correlation coefficient (HRVT: 0.55-0.85 and HRVT:0.58-0.69). All variables at HRVT and the heart rate at HRVT showed coefficient of variation ~ 10%. The HRVT, regardless of criteria and HRV index used, showed satisfactory reproducibility. Thus, these criteria can be used to assess clinically autonomic cardiac modulation and aerobic capacity, and to analyze the effect of different interventions.
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http://dx.doi.org/10.1055/a-0800-8633 | DOI Listing |
J Mol Cell Cardiol Plus
June 2024
Amsterdam UMC location Vrije Universiteit Amsterdam, Physiology, De Boelelaan 1118, Amsterdam, the Netherlands.
Few immortalized cardiac microvascular endothelial cell (CMEC) lines are available, particularly mouse lines. We purchased the CLU510 mCMEC line (Cedarlane), isolated by fluorescence-activated cell sorting for CD31 and VE-cadherin. The cell line has been used in previous studies, although none report CD31 or VE-cadherin expression.
View Article and Find Full Text PDFJ Perinat Med
January 2025
Perinatal Imaging Research Group, School of Clinical Medicine, Discipline of Women's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Objectives: Multiple techniques have been proposed for functional fetal cardiology, including pulsed-wave (PW) and tissue Doppler imaging (TDI), Myocardial Performance Index (MPI), annular plane systolic excursion (TAPSE/MAPSE) and spatiotemporal image correlation (STIC). We aimed to compare these techniques' achievability and reproducibility to determine their clinical utility for each cardiac side.
Methods: Uncomplicated pregnancies from 22 to 39 weeks were recruited and images and volumes stored for offline analysis.
Open Heart
January 2025
Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Background: Visual assessment of coronary CT angiography (CCTA) is time-consuming, influenced by reader experience and prone to interobserver variability. This study evaluated a novel algorithm for coronary stenosis quantification (atherosclerosis imaging quantitative CT, AI-QCT).
Methods: The study included 208 patients with suspected coronary artery disease (CAD) undergoing CCTA in Perfusion Imaging and CT Coronary Angiography With Invasive Coronary Angiography-1.
Open Heart
January 2025
Department of Molecular and Clinical Medicine, University of Gothenburg Institute of Medicine, Gothenburg, Sweden.
Purpose: We examined whether end-to-end deep-learning models could detect moderate (≥50%) or severe (≥70%) stenosis in the left anterior descending artery (LAD), right coronary artery (RCA) or left circumflex artery (LCX) in iodine contrast-enhanced ECG-gated coronary CT angiography (CCTA) scans.
Methods: From a database of 6293 CCTA scans, we used pre-existing curved multiplanar reformations (CMR) images of the LAD, RCA and LCX arteries to create end-to-end deep-learning models for the detection of moderate or severe stenoses. We preprocessed the images by exploiting domain knowledge and employed a transfer learning approach using EfficientNet, ResNet, DenseNet and Inception-ResNet, with a class-weighted strategy optimised through cross-validation.
Open Heart
January 2025
Department of Cardiology, University Hospital Basel, Basel, Switzerland.
Background: The majority of functional ischemia tests in patients with suspected chronic coronary syndromes (CCS) yield normal results. Implementing gatekeepers for patient preselection, such as pretest probability (PTP) and/or coronary artery calcium score (CACS), could reduce the number of normal scan results, radiation exposure and costs. However, the efficacy and safety of these approaches remain unclear.
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