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Disseminated nocardiosis in a patient with AIDS and B-cell non-Hodgkin's lymphoma: a case report.
BMC Infect Dis
January 2025
Department of Infectious Diseases, Hospital Universitario de Caracas, Caracas, Venezuela.
Background: Disseminated nocardiosis is a rare and potentially fatal disease, with a higher incidence in immunocompromised patients, such as those living with human immunodeficiency virus (HIV) or hematological malignancies, including lymphoma. Information on Nocardia spp. infection in Venezuela is limited.
View Article and Find Full Text PDFPathophysiology and clinical outcomes of pancytopenia in disseminated histoplasmosis: a scoping review.
Infection
January 2025
Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda.
Article Synopsis
- The study explores the relationship between pancytopenia (a decrease in blood cells) and disseminated histoplasmosis, noting that this connection is rarely documented in existing literature.
- The authors reviewed 72 cases worldwide, primarily from the Americas, finding that many patients had underlying conditions, such as HIV and haemophagocytic lymphohistiocytosis.
- Recovery rates were relatively high at 73.6%, but significant mortality was attributed to diagnostic delays and complications, indicating that early recognition of pancytopenia may be crucial for better patient outcomes.
Climate Change and Medical Mycology.
Infect Dis Clin North Am
December 2024
Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, ECMM Excellence Center, Auenbruggerplatz 15, Graz 8036, Austria; Translational Mycology, Medical University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address:
This review explores how climate change influences fungal disease dynamics, focusing on emergence of new fungal pathogens, increased antifungal resistance, expanding geographic ranges of fungal pathogens, and heightened host susceptibility. Rising temperatures and altered precipitation patterns enhance fungal growth and resistance mechanisms, complicating treatment efforts. Climate-driven geographic shifts are expanding the range of diseases like Valley fever, histoplasmosis, and blastomycosis.
View Article and Find Full Text PDFEvaluation of a commercial Histoplasma antigen detection enzyme immunoassay for the follow-up of histoplasmosis treatment in people living with HIV from Argentina.
Med Mycol
December 2024
Unidad Micología, Hospital de Enfermedades Infecciosas Dr. Francisco J. Muñiz, CABA, Argentina.
Article Synopsis
- Histoplasmosis is particularly dangerous for HIV patients, especially where antiretroviral therapy is hard to get, making antigen detection assays vital for quick diagnoses and reducing mortality.
- The study assessed 27 HIV patients with histoplasmosis over 24 weeks, monitoring urinary Histoplasma antigen levels as they received treatment with amphotericin B followed by itraconazole.
- Results indicated that as antigen levels decreased, patient clinical outcomes improved, suggesting that the clarus Histoplasma GM EIA kit could effectively monitor treatment responses, despite some patients having atypical antigen patterns due to immune system responses or medication absorption issues.
The "pseudo-pulmonary AVM sign": an aid to the diagnosis of histoplasmosis and differentiation from pulmonary arteriovenous malformations.
Curr Probl Diagn Radiol
December 2024
Department of Radiology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.
The diagnostic algorithm for histoplasmosis highlights the importance of imaging and emphasizes the role of the radiologist in the diagnostic workup. Here we describe a case series of patients with a novel sign of lung involvement in histoplasmosis which we have coined the Pseudo-Pulmonary Arteriovenous Malformation (PAVM) sign, the usage of which would help in the imaging diagnosis of histoplasmosis aid by distinguishing it from PAVMs. PAVMs carry risk for serious complications such as systemic emboli and may require treatment; whereas, histoplasmomas do not.
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