Cytotoxic epimeric ginsenosides from the flower buds of Panax ginseng.

Steroids

College of Life Science, Dalian Minzu University, Dalian 116600, People's Republic of China. Electronic address:

Published: March 2019

Three pairs of ginsenoside epimers, including three new compounds (2, 3 and 5), were isolated from the flower buds of Panax ginseng. The structures of the isolated compounds were elucidated on the basis of considerable spectroscopic analyses and comparison with the reported data. All six compounds were evaluated for their cytotoxicties against three human cancer cell lines, HL-60, MGC80-3 and Hep-G2. Compounds 1, 3, and 6 with S configurations at C-24 or C-20 showed moderate inhibitory activities with IC values of 25.32, 18.76, and 38.64 μM in HL-60 cells, respectively. Our findings showed that different configurations of these isolated ginsenosides had a significant impact on the antitumor activity, and S epimers were higher than R.

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http://dx.doi.org/10.1016/j.steroids.2018.12.002DOI Listing

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