Current fast imaging techniques are based on gradient echo sequences with reduced flip angle excitation pulses and very short repetition times TR. Practical T2 values may be of the order of TR or longer. In this situation, a different image contrast can be obtained, depending on details of the sequence. Four essentially different versions of the basic Fast Field Echo (FFE) sequence can be distinguished and are described systematically in this article. For these sequences, image contrast formulas are presented. Practical imaging should tolerate small field inhomogeneities. This requirement can be satisfied by only three of the four versions. Numerical simulations are used to study the influence of a modified phase alternation scheme on image contrasts of two of the remaining sequences. The results of the calculations are verified by phantom studies on a 1.5-T whole-body imager. Implications for contrast in clinical images are discussed in relation to head images obtained on the same machine.
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http://dx.doi.org/10.1016/0730-725x(88)90472-9 | DOI Listing |
Anal Chim Acta
February 2025
Engineering Research Center of Optical Instrument and System, Ministry of Education and Shanghai Key Lab of Modern Optical System, University of Shanghai for Science and Technology, No.516 Jungong Road, Shanghai, 200093, China.
Background: Surface-enhanced Raman scattering (SERS) has attracted much attention as a powerful detection and analysis tool with high sensitivity and fast detection speed. The intensity of the SERS signal mainly depended on the highly enhanced electromagnetic field of nanostructure near the substrate. However, the fabrication of high-quality SERS nanostructured substrates is usually complicated, makes many methods unsuitable for large-scale production of SERS substrates.
View Article and Find Full Text PDFMagn Reson Imaging
January 2025
Institute of Fluid Mechanics, University of Rostock, Rostock, Germany.
Purpose: To improve the current method for MRI turbulence quantification which is the intravoxel phase dispersion (IVPD) method. Turbulence is commonly characterized by the Reynolds stress tensor (RST) which describes the velocity covariance matrix. A major source for systematic errors in MRI is the sequence's sensitivity to the variance of the derivatives of velocity, such as the acceleration variance, which can lead to a substantial measurement bias.
View Article and Find Full Text PDFNutrients
January 2025
Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Non-celiac gluten/wheat sensitivity (NCGWS) is a syndrome for which pathogenesis and management remain debated. It is described as a condition characterized by gastrointestinal and extra-intestinal symptoms rapidly occurring after gluten ingestion in subjects who have had celiac disease or wheat allergy excluded. To date, the diagnosis of NCGWS is challenging as no universally recognized biomarkers have been yet identified, nor has a predisposing genetic profile been described.
View Article and Find Full Text PDFPharmaceuticals (Basel)
December 2024
Department of Nuclear Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstr. 74, 01307 Dresden, Germany.
(1) : Targeted alpha therapy is an emerging field in nuclear medicine driven by two advantages: overcoming resistance in cancer-suffering patients to beta therapies and the practical application of lower activities of Pb- and Ac-labelled peptides to achieve the same doses compared to beta therapy due to the highly cytotoxic nature of alpha particles. However, quality control of the Pb/Ac-radiopharmaceuticals remains a challenge due to the low activity levels used for therapy (100 kBq/kg) and the formation of several free daughter nuclides immediately after the formulation of patient doses; (2) : The routine alpha detection on thin-layer chromatograms (TLC) of Pb- and Ac-labelled peptides using a MiniScanPRO+ scanner combined with an alpha detector head was compared with detection using an AR-2000 scanner equipped with an open proportional counter tube. Measurement time, resolution and validity were compared for both scanners; (3) : For Ac, the quality control values of the radiochemical purity (RCP) were within the acceptance criteria 2 h after TLC development, regardless of when the TLC probe was taken.
View Article and Find Full Text PDFSensors (Basel)
January 2025
School of Physical Science and Technology, Ningbo University, Ningbo 315211, China.
Flexible, wearable, piezoresistive sensors have significant potential for applications in wearable electronics and electronic skin fields due to their simple structure and durability. Highly sensitive, flexible, piezoresistive sensors with the ability to monitor laryngeal articulatory vibration supply a new, more comfortable and versatile way to aid communication for people with speech disorders. Here, we present a piezoresistive sensor with a novel microstructure that combines insulating and conductive properties.
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