This article sets out to describe different value frameworks in the field of new developments in oncology. Since the costs of new oncological therapies follow a steep path, their implementation and financing demand a thorough assessment. This is an ambitious task due to the complex nature of oncological treatments within overall health policy. Five value frameworks were reviewed: European Society for Medical Oncology (ESMO) Magnitude of Clinical Benefit Scale, American Society of Clinical Oncology (ASCO) Value Framework (version 2.0), National Comprehensive Cancer Network (NCCN) Evidence Blocks, Memorial Sloan Kettering Cancer Center DrugAbacus, and the Institute for Clinical and Economic Review Value Assessment Framework. They are all based on a large set of criteria. However, all these frameworks differ considerably in their outcomes. Among the main differences one has to cite are the inclusion of costs and the use of different outcomes, as well as the fact that they address different target stakeholders, etc. Despite these shortcomings, the value frameworks serve the necessity to introduce more rationality in health decision making seen from the perspective of physicians, patients, and financing bodies.
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Appl Physiol Nutr Metab
January 2025
University of Toronto, Department of Nutritional Sciences, Toronto, Ontario, Canada;
The objective of this study was to develop and evaluate a Food Choices Assessment Score (FCAS) measuring alignment with 2019 Canada's Food Guide (CFG) and Canada's Dietary Guidelines (CDG) using a non-quantitative food frequency questionnaire (FFQ) data. Cross-sectional data from the Canadian Health Measures Survey (CHMS) (2016 to 2019), including 6,459 participants (≥19 years) and a non-quantitative FFQ (~100 food items) were used. Content and construct validity and assessing reliability were used to evaluate the FCAS, including a comparison of mean FCAS among Canadian subgroups, calculating the FCAS for high quality diet menus, investigating the consistency of the FCAS with the Dietary Approaches to Stop Hypertension (DASH), as a healthy diet linked with lower cardiometabolic risks, and estimating Cronbach's alpha for reliability.
View Article and Find Full Text PDFThe carbon dioxide (CO) capture and utilization strategy has emerged as an innovative and multifaceted approach to counteract carbon emissions. In this study, a highly porous muffin polyhedral barium (Ba) ̵ organic framework (BaTATB; HTATB = 4,4',4″--triazine-2,4,6-triyl-tribenzoic acid) was synthesized solvothermally. The three-dimensional honeycomb pore architectures were densely populated with Lewis acidic Ba(II) metal sites and basic nitrogen-rich triazines.
View Article and Find Full Text PDFFree Neuropathol
January 2024
Department of Pathology, Nash Family Department of Neuroscience, Department of Artificial Intelligence & Human Health, Neuropathology Brain Bank & Research CoRE, Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
This review highlights a collection of both diverse and highly impactful studies published in the previous year selected by the author from the neurodegenerative neuropathology literature. As with previous reviews in this series, the focus is, to the best of my ability, to highlight human tissue-based experimentation most relevant to experimental and clinical neuropathologists. A concerted effort was made to balance the selected studies across neurodegenerative disease categories, approaches, and methodologies to capture the breadth of the research landscape.
View Article and Find Full Text PDFExperiments have shown that predation-risk effects on prey fitness can be highly contingent on environmental conditions, suggesting a potential difficulty in generalizing risk effects on prey abundance in natural settings. Rather than study the influence of a particular controlled factor, we examine the problem with a novel approach. We examined the influence of risk effects in multiple experiments performed under similar study conditions.
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