AI Article Synopsis
- * Researchers have investigated whether using mechanical support pumps to lower the heart's oxygen demand can decrease heart damage in AMI since the 1970s.
- * Recent studies, including the Door to Unload ST-segment Elevation Myocardial Infarction (DTU-STEMI) pilot trial, have focused on modern circulatory support pumps to explore this approach further.
Article Abstract
Heart failure is a major cause of global morbidity and mortality. Acute myocardial infarction (AMI) is a primary cause of heart failure due in large part to residual myocardial damage despite timely reperfusion therapy. Since the 1970's, multiple preclinical laboratories have tested whether reducing myocardial oxygen demand with a mechanical support pump can reduce infarct size in AMI. In the past decade, this hypothesis has been studied using contemporary circulatory support pumps. We will review the most recent series of preclinical studies in the field which led to the recently completed Door to Unload ST-segment Elevation Myocardial Infarction (DTU-STEMI) safety and feasibility pilot trial.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259487 | PMC |
| http://dx.doi.org/10.12688/f1000research.14597.1 | DOI Listing |
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