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Scaling of Motor Output, From Mouse to Humans. | LitMetric
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Scaling of Motor Output, From Mouse to Humans.

Marin Manuel Matthieu Chardon Vicki Tysseling C J Heckman

Physiology (Bethesda)

Physiology, Physical Medicine and Rehabilitation, Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Published: January 2019

Appropriate scaling of motor output from mouse to humans is essential. The motoneurons that generate all motor output are, however, very different in rodents compared with humans, being smaller and much more excitable. In contrast, feline motoneurons are more similar to those in humans. These scaling differences need to be taken into account for the use of rodents for translational studies of motor output.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383635PMC
http://dx.doi.org/10.1152/physiol.00021.2018DOI Listing

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