Overexpression of forkhead box M1 is associated poor survival in patients with nonsmall cell lung cancer.

Aims: The association between forkhead box M1 (FOXM1) and survival of nonsmall cell lung cancer (NSCLC) has been extensively investigated. However, the results were conflicted and inconclusive. Therefore, we performed this meta-analysis to precisely estimate the association between FOXM1 and survival of NSCLC.

Materials And Methods: Studies were searched using the PubMed and EMBASE. The strength of the association was calculated with the hazard ratios (HRs) and respective 95% confidence intervals (CIs).

Results: Result of this meta-analysis showed that high expression of FOXM1 was significantly associated with shorter overall survival (OS) of NSCLC (HR = 1.82; 95% CI 1.45-2.29). In the stratified analysis by country, we found that the expression of FOXM1 was significantly associated with shorter OS in Chinese NSCLC patients (HR = 1.82; 95% CI 1.45-2.29). In addition, high expression of FOXM1 decreased the OS in patients with surgery (HR = 1.88; 95% CI 1.37-2.58). Furthermore, the results were still positive in both large sample size studies and small sample size studies.

Conclusions: This meta-analysis showed that overexpression of FOXM1 might be associated with shorter OS of NSCLC patients.