AI Article Synopsis
- The study evaluates the effectiveness of the Appleby operation in treating pancreatic cancer, analyzing patient outcomes over several weeks and noting key health metrics before and after surgery.
- The operation was performed on 17 patients, resulting in significant pain relief, improved body weight, and enhanced quality of life, despite a notable complication rate of 47.1%.
- The 1-, 2-, 3-, and 5-year survival rates post-surgery were 80.4%, 54.2%, 32.5%, and 16.3%, respectively, indicating that the Appleby operation is a viable option for managing this condition.*
Article Abstract
Aims: The aim of this study is to evaluate the therapeutic efficacy of Appleby operation for carcinoma of the body and tail of pancreas.
Materials And Methods: From March 2010 to February 2015, Appleby operation was performed in 17 patients with carcinoma of the body and tail of pancreas. The values of fasting plasma blood, body weight (BW), visual analog pain intensity scale (VAS score), and the quality of life indices were evaluated before and 1 day, 1, 2, 6 weeks after surgery. Survival time, tumor recurrence time, hospitalization time, and treatment-related complications were analyzed.
Results: There was no hospital mortality. Pancreatic fistula and diarrhea were major and most frequent. The rate of morbidity in general was 47.1%. After operation, all of the patients were completely pain-free. The VAS score decreased more after surgery comparing with before (83.2 ± 8.5 vs. 1.9 ± 3.6, P < 0.05). After operation, patients gained more than their preoperative BW with a mean increment of (4.1 ± 1.3 kg) (68.1 ± 4.3 vs. 64.0 ± 6.7, P < 0.05). A significant rise of the overall quality of life index was observed after surgery (93.8 ± 9.7 vs. 68.6 ± 6.7, P < 0.05). The 1-, 2-, 3-, and 5-year recurrence rates were 22.9%, 58.9%, 72.6%, and 72.6%, respectively. The 1-, 2-, 3-, and 5-year survival rates after operation were 80.4%, 54.2%, 32.5%, and 16.3%, respectively.
Conclusions: Appleby operation is both safe and effective with regard to pain relief and improvement of overall quality of life. Appleby operation can also achieve a high survival rate and a long overall survival time.
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| http://dx.doi.org/10.4103/0973-1482.199383 | DOI Listing |
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