AI Article Synopsis
- The study aimed to assess various strategies to lower the incidence of early onset GBS sepsis (EOGBS) in newborns in Israel, utilizing a risk allocation model.
- Results indicated that antepartum screening (APS) and intrapartum prophylaxis (IAP) could significantly decrease EOGBS attack rates, with rapid intrapartum testing enhancing effectiveness further.
- The conclusion emphasized that combining IAP with postpartum antibiotic prophylaxis (PAP) could cut the current EOGBS rates by around 40%, making a selective approach to screening and treatment the most effective method.
Article Abstract
Objective: To quantify effects of different strategies for decreasing neonatal early onset GBS sepsis (EOGBS) in Israel.
Study Design: A risk allocation model for EOGBS among infants ≥ 35w was adapted to Israeli data. Effects of strategies for antepartum (APS) and intrapartum (IPS) screening, and intrapartum (IAP) and/or postpartum antibiotic prophylaxis (PAP) were calculated.
Results: Estimated EOGBS attack rates (AR) with APS in 90%, IAP in 90%, may reduce AR to 0.18/1000. A rapid intrapartum test would further decrease AR to 0.16/1000, while reducing IAP from 21.3 to 12.5% of women. For babies with risk factors and GBS+ who do not receive IAP, further risk reduction could be achieved by PAP.
Conclusion: IAP remains the main intervention to decrease EOGBS. IAP and PAP together may reduce EOGBS present incidence by 40%. Combining rapid intrapartum screening with selective IAP and selective PAP for remaining gaps, would be the most efficient strategy.
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| http://dx.doi.org/10.1038/s41372-018-0289-2 | DOI Listing |
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