AI Article Synopsis
- - Bladder cancer is a prevalent and serious cancer affecting the urinary system, with current treatments including surgery, radiation, and chemotherapy, but there's a pressing need for new therapeutic targets to improve patient outcomes.
- - The study identified RAB38 as a protein linked to advanced bladder cancer features, such as higher stages and likelihood of recurrence, with its depletion leading to reduced cancer cell growth and movement.
- - Overall, the findings suggest that RAB38 plays a crucial role in bladder cancer progression, making it a potential new target for treatment strategies.
Article Abstract
Background: Bladder cancer is the most common malignancy of urinary system with high morbidity and mortality. In general, the development and progression of bladder cancer are complicated pathological processes, and the treatment methods mainly include surgical resection, radiotherapy, chemotherapy, and combined therapy. In recent years, targeted therapy has made progress in the treatment of bladder cancer. Therefore, to improve survival rates of patients with advanced bladder cancer, novel therapeutic targets are still urgently needed.
Methods And Results: In this study, we found that RAB38 expressed in tumor tissues of patients with bladder cancer was linked to clinical features including pTNM stage and tumor recurrence, and positively correlated with the poor prognosis of bladder cancer. Notably, further results indicated that depletion of RAB38 could significantly inhibit the proliferation and motility of two types of human bladder cancer cells, T24 and 5637 cells. In addition, RAB38 ablation obviously blocked tumor growth and development in mice compared with control.
Conclusion: In conclusion, this study provides significant evidence that RAB38 promotes the development of bladder cancer and provides a novel therapeutic target of bladder cancer.
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| http://dx.doi.org/10.1007/s00345-018-2596-9 | DOI Listing |
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