Background: The increase of invasive fungal disease (IFD) in immunocompromised patients has led to the frequent prescription of highly active antifungal drugs but with a high economic cost.
Aim: To characterize the use of antifungals drugs, evaluate its prescription and determine consumption and associated costs.
Methods: Retrospective descriptive study from January 2015 to April 2016. Audit of prescriptions and review of clinical files. Each prescription was classified according to whether it corresponded to a possible, probable or proven invasive fungal disease (IFD). Consumptions and treatment costs were calculated.
Results: 152 antifungal prescriptions were audited in 79 patients. The total cost of antifungal medications was US $ 714,413. 52.1% of the expenditure (US $ 372,319) corresponded to indications in proven IFD, 10.7% (US $ 76,377) probable IFD, 0.8% (US $ 5,638) non-IFI, 12.2% (US $ 87,459) IFD possible and 1.5% (US $ 10,896) non-IFD and 22.6% (US $ 161,723) was prophylaxis. The highest consumption was in indications related to IFD tested with a proven DOT of 10.54 days, with liposomal amphotericin B and iv voriconazole the drugs with the highest consumption with a DOT probable_AnBL of 3.15 and DOT proven voriconazole iv of 3.01.
Conclusions: The consumption of antifungal drug medications generates high costs at 12% of the total pharmacy budget of our institution. The expense was associated mainly with the indications in IFI tested the voriconazole and amphotericin B liposomal with the highest consumption which added to its high cost and prolonged days of general therapy a big impact in the budget.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4067/s0716-10182018000400351 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Federal University of São Carlos, São Carlos, Brazil.
Background: Informal care of older adults impacts the lives of millions worldwide. Critically, low- and middle-income countries have the highest proportion of dementia costs related to informal care. Research suggests that older adults' cognitive decline is associated with burden among caregivers, which corroborates the worsening in caregivers' quality of life and mental health.
View Article and Find Full Text PDFPrecision Opioid Prescription in ICU Surgery: Insights from an Interpretable Deep Learning Framework.
J Surg (Lisle)
November 2024
Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Purpose: Appropriate opioid management is crucial to reduce opioid overdose risk for ICU surgical patients, which can lead to severe complications. Accurately predicting postoperative opioid needs and understanding the associated factors can effectively guide appropriate opioid use, significantly enhancing patient safety and recovery outcomes. Although machine learning models can accurately predict postoperative opioid needs, lacking interpretability hinders their adoption in clinical practice.
View Article and Find Full Text PDFSustainable high-yield farming is essential for bending the curve of biodiversity loss.
Philos Trans R Soc Lond B Biol Sci
January 2025
Department of Zoology, University of Cambridge, Cambridge, UK.
Food production does more damage to wild species than any other sector of human activity, yet how best to limit its growing impact is greatly contested. Reviewing progress to date in interventions that encourage less damaging diets or cut food loss and waste, we conclude that both are essential but far from sufficient. In terms of production, field studies from five continents quantifying the population-level impacts of land sharing, land sparing, intermediate and mixed approaches for almost 2000 individually assessed species show that implementing high-yield farming to spare natural habitats consistently outperforms land sharing, particularly for species of highest conservation concern.
View Article and Find Full Text PDFEgg consumption, sleep, and mental health status among women with type II diabetes.
Sci Rep
January 2025
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P. O. Box: 1416643931, Tehran, Iran.
To evaluate if egg consumption is associated with sleep quality and psychological health (depression, anxiety, and stress) in women with type 2 diabetes. A cross-sectional study was conducted on women with type 2 diabetes (n = 230). Weight, height, waist circumference (WC), and blood pressure were measured.
View Article and Find Full Text PDFEvaluation of mechanical and thermal stress in an endodontically treated cracked premolar with three restorative designs: 3D-finite element analysis.
J Prosthodont Res
January 2025
Center of Stomatology, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Purpose: We aimed to analyze the influence of different designs (inlay, onlay, and crown) on stress distribution and crack propagation in an endodontically treated cracked premolar.
Methods: Three-dimensional (3D) finite element analysis (FEA) was employed to model an endodontically treated cracked premolar with three different restorations (inlay, onlay, and crown). Six types of loadings (vertical loading of 600 N; hot thermal-600 N vertical coupling loading; cold thermal-600 N vertical coupling loading; oblique loading of 200 N; hot thermal-200 N oblique coupling loading; cold thermal-200 N oblique coupling loading) were applied to simulate the hot and cold food/beverages intake.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!