AI Article Synopsis
- The study investigates the effectiveness of various immunologic tests for diagnosing neurocysticercosis (NC) in patients, comparing results from serum and cerebrospinal fluid (CSF) samples.
- A case-control study in Cuenca, Ecuador, enrolled 24 NC patients and 18 other neurosurgical patients, using different antigen and DNA detection methods including HP10 antigen assays and PCR in CSF.
- Results showed that the HP10 Ag assay in CSF and PCR were particularly effective, especially for cases of extraparenchymal NC, suggesting they could serve as valuable diagnostic tools alongside neuroimaging.
Article Abstract
The role of immunologic tests in the diagnosis of neurocysticercosis (NC) is controversial and few studies have made comparisons among them. The objective of this study was to compare immunological tests in both serum and cerebrospinal fluid (CSF) for the diagnosis of NC. We conducted a case-control study in Cuenca, Ecuador, enrolling patients with NC (N = 24) and matching them with other neurosurgical patients (N = 18). To detect cysticercal antigen, we used an HP10 antigen assay in serum and CSF ("HP10 Ag -serum -CSF") and a commercial antigen assay in serum (apDia, "ELISA-Ag-serum"), and to detect cysticercal DNA, we used a polymerase chain reaction (PCR) assay in CSF ("PCR-CSF"). Assay sensitivities were: HP10 Ag-serum (41.7%, 95% confidence interval [CI] 22.1-63.4), HP10 Ag-CSF (87.5%, 95% CI: 67.6-97.3), ELISA-Ag-serum (62.5%, 95% CI: 40.6-81.2), and PCR-CSF (79.2%, 95% CI: 57.9-92.9). Sensitivities were higher when limiting to participants with extraparenchymal NC. Specificity was 100% for all assays except ELISA-Ag-serum (72.2%). This preliminary study demonstrated the potential usefulness of the PCR and HP10 Ag assay in CSF, especially for extraparenchymal NC; thus, they could be considered as complementary diagnostic tools when neuroimaging is not conclusive.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278713 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2018.e00991 | DOI Listing |
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