Alterations in RNA metabolism play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. The literature has described, so far, a small number of long non coding RNAs (lncRNAs) associated to ALS demonstrating that how there is still much to do to identify and understand their role in ALS. This class of RNAs may offer numerous starting points for new investigations about pathogenic mechanism involved in ALS disease. In this review, we have collected all the presented data about lncRNAs and ALS to offer an overview about this class of non-coding RNAs and their possible role in ALS disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260474 | PMC |
| http://dx.doi.org/10.1016/j.ncrna.2018.11.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chromosome-scale genome assembly of Korean goosegrass (Eleusine indica).
Sci Data
January 2025
Department of Crop Science, Chungnam National University, Daejeon, 34134, Republic of Korea.
Goosegrass, belonging to the genus Eleusine within the Chloridoideae subfamily, is often one of the problematic weeds with strong invasiveness, competing with crops for essential survival resources. Although a chromosome-level genome assembly of E. indica from China was published last year, the present research focuses on a population of E.
View Article and Find Full Text PDF[Effects of long non-coding RNA KLHL7-AS1 on the proliferation and apoptosis of nucleus pulposus cells under the environment of oxidative stress and its mechanism].
Zhonghua Yi Xue Za Zhi
February 2025
Department of Orthopedics, the First Hospital of Huaian City, Nanjing Medical University, Huaian 223300, China.
To investigate the effects of long non-coding RNA KLHL7-AS1 (LncRNA KLHL7-AS1) on the proliferation and apoptosis of nucleus pulposus cells under oxidative stress and its mechanisms. Human nucleus pulposus cells (HUM-iCell-s012) were divided into 4 groups, and unoxidized nucleus pulposus cells were transfected with an empty pcDNA vector (pcDNA-control) to serve as the blank control group. Based on previous studies on oxidative stress-induced nucleus pulposus cell senescence and preliminary experiments, oxidative stress was induced by treating nucleus pulposus cells with 400 μmol/L HO.
View Article and Find Full Text PDFObjectives Family caregivers of individuals with young-onset dementia (YOD) often struggle to seek help, despite the heavy burden of care. This study explored their feelings when attempting to find support in the early stages after diagnosis.Methods This qualitative descriptive study conducted semi-structured interviews with eight family caregivers of patients with YOD at home.
View Article and Find Full Text PDFPredictive value and mechanism of lncRNA MANCR for pediatric severe pneumonia via miR-20a-5p / MAPK1 axis.
Immunobiology
January 2025
Department of Pediatrics, Chinese and Western Medicine Hospital of Panzhihua, Panzhihua 617099, China.
Severe community-acquired pneumonia (SCAP) significantly threats the safety of children's lives. Long non-coding RNA (lncRNA) MANCR is overexpressed in lung adenocarcinoma (LUAD) tissue, promote the proliferation, invasion, and migration, decreased cell apoptosis of LUAD cells. This study aimed to detect lncRNA MANCR levels in pediatric SCAP, and explore the diagnostic and prognostic significance of MANCR in pediatric SCAP.
View Article and Find Full Text PDFChronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease.
Toxicology
January 2025
Yangzhou University Medical College, Yangzhou University, Yangzhou, Jiangsu Province 225009, China; Jiangsu Key Laboratory of Non coding RNA Basic and Clinical Transformation, Yangzhou University, Yangzhou, Jiangsu Province 225009, China. Electronic address:
Microplastics (MPs), as the crucial environmental pollutants, can be easily transported into the human body and accumulate in the liver. However, current studies mainly focus on acute exposure to MPs, investigations on long-term interactions with MPs alone remain limited. Thereby, we examined noxious properties of MPs and selected the most common polystyrene (PS) MPs as the research object, including unmodified PS MPs (PS-MPs) and positive-charged PS MPs (PS-NH) at 10 mg/L employing oral drinking water methods in mice for six consecutive months in vivo.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!