Syncope is defined as a transient loss of consciousness due to cerebral hypoperfusion characterized by rapid onset, short duration, and spontaneous complete recovery. Numerous causes of syncope have been described. Vasovagal syncope is the most common with a number of precipitants. We report a case of post herpetic trigeminal neuralgia leading to neurocardiogenic syncope. These episodes were preceded by severe stabbing left frontal headaches followed by significant sinus bradycardia, asystole, and syncope requiring pacemaker implantation. To our knowledge only one previous case of post herpetic trigeminal neuralgia leading to syncope has been reported. < Neuralgia-associated syncope is a rare phenomenon. Failing to recognize and treat appropriately may be associated with recurring episodes of syncope with significant lifestyle limitations. Although post herpetic neuralgia is treatable, one should be prepared to insert a pacemaker if treatment fails to control symptoms that progress to cardioinhibitory syncope.>.
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http://dx.doi.org/10.1016/j.jccase.2013.02.007 | DOI Listing |
Cell Rep
December 2024
School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address:
Alzheimer's disease (AD) diagnosis relies on the presence of extracellular β-amyloid (Aβ) and intracellular hyperphosphorylated tau (p-tau). Emerging evidence suggests a potential link between AD pathologies and infectious agents, with herpes simplex virus 1 (HSV-1) being a leading candidate. Our investigation, using metagenomics, mass spectrometry, western blotting, and decrowding expansion pathology, detects HSV-1-associated proteins in human brain samples.
View Article and Find Full Text PDFActa Derm Venereol
January 2025
Ben Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel; Pediatric Dermatology Service, Soroka University Medical Center, Beer-Sheva, Israel.
This study investigates serum cell-free DNA fluctuations in patients with herpes zoster or post-herpetic neuralgia, offering insight into the tissue damage and inflammatory dynamics associated with these conditions. A single-centre combined cross-sectional and longitudinal study was conducted with 59 patients to assess cell-free DNA levels in herpes zoster and post-herpetic neuralgia. Cell-free DNA was extracted from blood samples of patients with herpes zoster or post-herpetic neuralgia and compared with healthy controls.
View Article and Find Full Text PDFCureus
November 2024
Department of Pain Medicine, Fondazione Paolo Procacci, Rome, ITA.
The present investigation evaluated transcutaneous electrical nerve stimulation (TENS) for the non-pharmacological treatment of post-herpetic neuralgia (PHN). PHN is the most common complication of the Herpes Zoster virus, affecting one in every five patients with shingles, and presents as intense neuropathic pain that can persist for 90 days or longer after the initial onset of symptoms. Current pharmacological treatment options are mainly limited to symptom management, including oral medications such as tricyclic antidepressants and gabapentinoid preparations, as well as topical options such as lidocaine or capsaicin.
View Article and Find Full Text PDFCureus
November 2024
Physical Medicine and Rehabilitation, RG Kar Medical College and Hospital, Kolkata, IND.
A 44-year-old male patient experienced persistent radiating pain from the elbow to the hand following herpes zoster vesicular eruptions three months earlier. His examination met the Budapest Clinical Criteria for Complex Regional Pain Syndrome (CRPS), revealing sensory, motor, vasomotor, and sudomotor signs and symptoms. Despite conservative treatments, the pain persisted.
View Article and Find Full Text PDFRev Med Liege
December 2024
Service de Dermatologie et Vénéréologie, CHU Liège, Belgique.
Shingles, also termed herpes zoster (HZ), is due to the reactivation of the varicella zoster virus (VZV) in a dorsal root nerve ganglion with an intra-axonal passage of the virus to a predetermined dermatome. The risk of HZ increases with age, as well as the morbidity risks. The most feared complication is post-herpetic neuralgia, defined as persisting pain sensations three months after the resolution of the skin lesions.
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