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Polyphenol Analysis and Antibacterial Potentials of Twig Extracts of , , and Growing Naturally in Finland.
Int J Mol Sci
November 2024
Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, 00100 Helsinki, Finland.
species have been used in traditional medicine to treat fever and inflammation. However, there is no reported information on the antibacterial activities of and , and little is known about the phytochemistry of . In this study, winter-dormant twig extracts of , , and were screened for their antibacterial activities against , , , and .
View Article and Find Full Text PDFEradication of Persister Cells by Eravacycline.
ACS Infect Dis
December 2024
Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York 13244, United States.
is a leading bacterial pathogen that causes persistent infections. One major reason that antibiotics fail to clear such infections is the presence of a dormant subpopulation called persister cells. To eradicate persister cells, it is important to change drug development from traditional strategies that focus on growth inhibition to the search for new leads that can kill dormant cells.
View Article and Find Full Text PDFUnderstanding the autophagic functions in cancer stem cell maintenance and therapy resistance.
Expert Rev Mol Med
October 2024
Department of Biochemistry, University of Lucknow, Lucknow 226007, India.
Complex tumour ecosystem comprising tumour cells and its associated tumour microenvironment (TME) constantly influence the tumoural behaviour and ultimately impact therapy failure, disease progression, recurrence and poor overall survival of patients. Crosstalk between tumour cells and TME amplifies the complexity by creating metabolic changes such as hypoxic environment and nutrient fluctuations. These changes in TME initiate stem cell-like programmes in cancer cells, contribute to tumoural heterogeneity and increase tumour robustness.
View Article and Find Full Text PDFPhotoinactivation of and by Near-Infrared Radiation Using a Trehalose-Conjugated Heptamethine Cyanine.
Int J Mol Sci
August 2024
A.N. Bach Institute of Biochemistry, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia.
The spread of multidrug-resistant mycobacterium strains requires the development of new approaches to combat diseases caused by these pathogens. For that, photodynamic inactivation (PDI) is a promising approach. In this study, a tricarbocyanine (TCC) is used for the first time as a near-infrared (740 nm) activatable PDI photosensitizer to kill mycobacteria with deep light penetration.
View Article and Find Full Text PDFDeath at a funeral: Activation of the dead enzyme, MLKL, to kill cells by necroptosis.
Curr Opin Struct Biol
October 2024
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. Electronic address:
Necroptosis is a lytic form of programmed cell death implicated in inflammatory pathologies, leading to intense interest in the underlying mechanisms and therapeutic prospects. Here, we review our current structural understanding of how the terminal executioner of the pathway, the dead kinase, mixed lineage kinase domain-like (MLKL), is converted from a dormant to killer form by the upstream regulatory kinase, RIPK3. RIPK3-mediated phosphorylation of MLKL's pseudokinase domain toggles a molecular switch that induces dissociation from a cytoplasmic platform, assembly of MLKL oligomers, and trafficking to the plasma membrane, where activated MLKL accumulates and permeabilises the lipid bilayer to induce cell death.
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