Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4103/ijmy.ijmy_127_18 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring Mycolactone-The Unique Causative Toxin of Buruli Ulcer: Biosynthetic, Synthetic Pathways, Biomarker for Diagnosis, and Therapeutic Potential.
Toxins (Basel)
December 2024
Department of Chemistry, University of Ghana, Legon-Accra P.O. Box LG56, Ghana.
Mycolactone is a complex macrolide toxin produced by , the causative agent of Buruli ulcer. The aim of this paper is to review the chemistry, biosynthetic, and synthetic pathways of mycolactone A/B to help develop an understanding of the mode of action of these polyketides as well as their therapeutic potential. The synthetic work has largely been driven by the desire to afford researchers enough (≥100 mg) of the pure toxins for systematic biological studies toward understanding their very high biological activities.
View Article and Find Full Text PDFNon tuberculous Mycobacterial Surgical Site Infections after Laparoscopic Surgery: A Case Series of 37 Patients.
Int J Mycobacteriol
October 2024
Department of General Surgery, University College of Medical Sciences, New Delhi, India.
Nontuberculous mycobacterial surgical site infections (SSIs) have a distinct course of disease with diagnosis and treatment presenting challenges. Thirty-seven patients who underwent various procedures and then developed late SSI due to nontuberculous mycobacteria included in this case series. Samples were sent for diagnosis.
View Article and Find Full Text PDFNon-Tuberculous Mycobacteria: Single Center Analyses of Risk Factors, Management and Mortality Outcomes of Adults with HIV.
Diagnostics (Basel)
November 2024
Department of Internal Medicine, University of Witwatersrand, Johannesburg 2193, South Africa.
Background/objectives: In sub-Saharan Africa, there is paucity of data regarding non-tuberculous mycobacterial (NTM) infections, leading to underappreciation of disease burden. Consequently, fewer resources are allocated, leading to potential adverse outcomes. This study examines long-term mortality and risk factors of South African patients with positive NTM samples.
View Article and Find Full Text PDFAdjunctive Diagnosis of Pneumonia by Metagenomic Next-Generation Sequencing in an Immunocompetent Patient: A Case Report and Literature Review.
Infect Drug Resist
December 2024
Department of Respiratory Medicine, The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Introduction: is a nonpathogenic pathogen commonly found in nature and is generally considered a contaminant in clinical practice. Although there have been few reported cases of infection, most of them are secondary to immunosuppression. This paper described a rare case of globular shadow in the chest of an immunocompetent male who was diagnosed with pulmonary disease.
View Article and Find Full Text PDFCyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus.
J Biomed Sci
December 2024
CNRS, LISM UMR7255, IMM-FR3479, Aix-Marseille Univ, Marseille, France.
Background: Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive pulmonary disease. Macrolides, such as clarithromycin (CLR) or azithromycin (AZM), represent the cornerstone of antibiotherapy against the M. abscessus species.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!