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Teaching Video NeuroImage: Minipolymyoclonus: A Clinical Clue to Spinal Muscular Atrophy.
Neurology
February 2025
Division of Neuromuscular Diseases, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, Brazil.
Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associations.
Sci Adv
January 2025
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
We applied an MRI technique diffusion tensor imaging along the perivascular space (DTI-ALPS) for assessing glymphatic system (GS) in a genome-wide association study (GWAS) and phenome-wide association study (PheWAS) of 40,486 European individuals. Exploratory analysis revealed 17 genetic loci significantly associating with the regional DTI-ALPS index. We found 58 genes, including and , which prioritized in the DTI-ALPS index subtypes and associated with neurodegenerative diseases.
View Article and Find Full Text PDFDiabetes-related cognitive impairment: Mechanisms, symptoms, and treatments.
Open Med (Wars)
January 2025
Endocrine Department, 920th Hospital of Joint Logistics Support Force, PLA, No. 212 Daguan Road, Xishan District, Kunming, 650000, Yunnan, China.
Background: Diabetes-related cognitive impairment is increasingly recognized as a significant complication, profoundly impacting patients' quality of life. This review aims to examine the pathophysiological mechanisms, clinical manifestations, risk factors, assessment and diagnosis, management strategies, and future research directions of cognitive impairment in diabetes.
Methodology: A comprehensive literature search was conducted using PubMed, Medline, and other medical databases to identify, review, and evaluate published articles on cognitive impairment in diabetes.
The Impact of Executive Function on Retention and Compliance in Physical Therapy in Veterans.
Arch Rehabil Res Clin Transl
December 2024
New England Geriatric Research, Education and Clinical Center, VA Boston Healthcare System, Boston MA.
Objective: To examine retention and compliance to a novel physical therapy (PT) treatment among Veterans with and without executive function deficits (EFD+/EFD-).
Design: This study was a preplanned secondary analysis of an ongoing randomized controlled trial.
Setting: Outpatient PT at VA Boston Healthcare System.
Emotion regulation strategy and its relationship with emotional dysregulation in children with attention-deficit/hyperactivity disorder: behavioral and brain findings.
Eur Child Adolesc Psychiatry
January 2025
NHC Key Laboratory of Mental Health (Peking University), Peking University Sixth Hospital, Institute of Mental Health, Beijing, 100191, China.
Important associations between emotional dysregulation (ED) and ADHD have been identified in adults, with a key manifestation of this being differential use of emotion regulation strategies: reduced use of cognitive reappraisal (CR), but elevated expressive suppression (ES). These associations have been observed at both behavioral and neuroimaging levels. The present study aims to explore the use of CR and ES in children with ADHD, and their relationship to ED.
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