Concomitant reactions to palladium chloride (PdCl), sodium tetrachloropalladate (NaPdCl), and nickel hexahydrate sulphate (NiSO·6HO) are very common during patch testing and have mainly been explained by cross-sensitisation. Whether there is variation in reactivity to palladium or covariation to nickel and palladium is not known. The aim of this study was to investigate the variation in patch test reactivity to PdCl and NaPdCl over time and compare this to variation in patch test reactivity to NiSO·6HO. Fifteen females known to be sensitised to nickel and palladium were patch tested four times with 12-week intervals using a dilution series of NiSO·6HO, PdCl or NaPdCl. Patch test reactivity to NaPdCl was less variable compared to that for NiSO·6HO or PdCl. All test salts showed higher patch test reactivity during wintertime. No significant correlation was observed between the variation in patch test reactivity to NaPdCl and PdCl and the variation in patch test reactivity to NiSO·6HO during the entire test period. Patch test reactivity to NaPdCl is less variable over time compared to that for PdCl or NiSO·6HO. No clear covariation was identified between tests for palladium salts and NiSO·6HO. The variation in patch test reactivity found in this study could be due to seasonal changes.
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