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WNT4 promotes the symmetric fission of crypt in radiation-induced intestinal epithelial regeneration.
Cell Mol Biol Lett
December 2024
Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Background: Radiotherapy for pelvic malignant tumors inevitably causes intestinal tissue damage. The regeneration of intestinal epithelium after radiation injury relies mainly on crypt fission. However, little is known about the regulatory mechanisms of crypt fission events.
View Article and Find Full Text PDFSynergistic effect of inulin hydrogels on multi-strain probiotics for prevention of ionizing radiation-induced injury.
Int J Biol Macromol
December 2024
School of Pharmacy, Anhui Medical University, Hefei 230032, China; Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address:
Prebiotics and probiotics are applied against multiple diseases including ionizing radiation-induced injury but their functions are not revealed enough. Here, we used a prebiotic, inulin hydrogels (IGs) to load multi-strain probiotics (MSPs) for protecting them from the gastrointestinal environment and improving their colonization in the gut; more importantly, they showed the synergistic effect against ionizing radiation-induced injury. Probiotics were embedded in a great number of channels of the IGs and used IGs as food.
View Article and Find Full Text PDFVasoactive intestinal peptide promotes secretory differentiation and mitigates radiation-induced intestinal injury.
Stem Cell Res Ther
October 2024
Department of Internal Medicine II, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Article Synopsis
- Vasoactive intestinal peptide (VIP) plays a crucial role in intestinal health, influencing epithelial cell turnover and differentiation, especially under injury conditions like irradiation.
- VIP promotes the differentiation of intestinal epithelial cells and boosts progenitor cell proliferation, primarily through the p38 MAPK signaling pathway.
- In mouse models, VIP not only enhances recovery from radiation-induced damage but also demonstrates potential protective effects on intestinal cells during injury.
Pelvic Radiation Therapy Increases Risk of Pouch Failure in Patients with Inflammatory Bowel Disease and Ileal Pouch.
Dig Dis Sci
September 2024
Division of Gastroenterology and Hepatology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL, 32224, USA.
Background: The effect of radiation on the ileal pouch is less well studied in patients with inflammatory bowel disease (IBD) and ileal pouch-anal anastomosis.
Aims: This retrospective study investigates the impact of external radiation therapy on the outcomes of ileal pouches.
Methods: The study included 82 patients with IBD and ileal pouches, of whom 12 received pelvic radiation, 16 abdominal radiation, 14 radiation in other fields, and 40 served as controls with no radiation.
Selecting the Most Relevant Mouse Strains for Evaluating Radiation-Induced Multiple Tissue Injury after Leg-Shielded Partial-Body Gamma Irradiation.
Radiat Res
September 2024
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Animal studies are needed that best simulate a large-scale, inhomogeneous body exposure after a radiological or nuclear incident and that provides a platform for future development of medical countermeasures. A partial-body irradiation (PBI) model using 137Cs gamma rays with hind limb (tibia) shielding was developed and assessed for the sequalae of radiation injuries to gastrointestinal tract, bone marrow (BM) and lung and among different genetic mouse strains (C57BL/6J, C57L/J, CBA/J and FVB/NJ). In this case, a marginal level of BM shielding (∼2%) provided adequate protection against lethality from infection and hemorrhage and enabled escalation of radiation doses with evaluation of both acute and delayed radiation syndromes.
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