AI Article Synopsis
- * In a study using a chemically-induced model of oral cancer in rats, researchers found an increase in MSCs and a decrease in T cells in precancerous and cancerous lesions.
- * The study also showed that MSCs enhanced immunosuppression of T cells and higher MSC presence correlated with increased cellular proliferation in the lesions, suggesting MSCs play a key role in malignant transformation of oral mucosa by regulating T cell activity.
Article Abstract
Recent evidences suggested that Mesenchymal stem cells (MSCs) may be involved in tumor formation by modulating of the tumor microenvironment, but it is still unclear the potential of MSCs in the malignant transformation of oral mucosa. Using a chemically-induced oral carcinogenesis model by 4-nitroquinoline-1-oxide (4NQO), we generated precancerous lesions and cancerous lesions in the oral cavity of rats. Flow cytometric analysis on lesions derived single cell suspension revealed an increase in the proportion of MSCs and a decreased proportion of T cell during oral mucosa malignancy. Moreover, MSCs showed increased immunosuppression capacity on T cell proliferation during mucosa malignancy. At last, we demonstrated that higher frequency of lesions resident MSCs was correlated with more Ki67 expression in the lesion, which indicated higher cellular proliferative status in the lesions. Our study demonstrated that MSCs may play an important role in oral mucosa malignant transformation through regulating T cell proliferation.
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| http://dx.doi.org/10.1016/j.clim.2018.12.001 | DOI Listing |
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