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Antibiotic-mediated dysbiosis leads to activation of inflammatory pathways.
Front Immunol
January 2025
Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Introduction: The gut microbiota plays a pivotal role in influencing host health, through the production of metabolites and other key signalling molecules. While the impact of specific metabolites or taxa on host cells is well-documented, the broader impact of a disrupted microbiota on immune homeostasis is less understood, which is particularly important in the context of the increasing overuse of antibiotics.
Methods: Female C57BL/6 mice were gavaged twice daily for four weeks with Vancomycin, Polymyxin B, or PBS (control).
Squamate reptiles may have compensated for the lack of γδTCR with a duplication of the TRB locus.
Front Immunol
January 2025
Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, United States.
Squamate reptiles are amongst the most successful terrestrial vertebrate lineages, with over 10,000 species across a broad range of ecosystems. Despite their success, squamates are also amongst the least studied lineages immunologically. Recently, a universal lack of γδ T cells in squamates due to deletions of the genes encoding the T cell receptor (TCR) γ and δ chains was discovered.
View Article and Find Full Text PDFGut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics study.
World Allergy Organ J
January 2025
Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, PR China.
Background: Many studies reported the influence of infants' gut microbiota on atopic dermatitis (AD) postnatally, yet the role of maternal gut microbiota and plasma metabolites in infants' AD remains largely unexplored.
Methods: Sixty-three pregnant mother-infants were enrolled and followed after childbirth in Guangzhou, China. Demographic information, maternal stool and plasma samples, and records for infants' AD were collected.
Study on the Brill transition of polyamide 6 with different crystal forms using low- and high-frequency Raman spectroscopy.
RSC Adv
January 2025
Graduate School of Human Development and Environment, Kobe University 3-11, Tsurukabuto, Nada-ku Kobe Hyogo 657-0011 Japan
Polyamide 6 (PA6) in its α and γ-forms was studied from 30 to 220 °C using Raman spectroscopy in the low- and high-wavenumber regions. Quantum chemical calculations were employed to assist with band assignments. In the low-wavenumber region, a peak at approximately 100 cm, attributable to a mixed mode of methylene lateral motion and amide group stretching, was observed.
View Article and Find Full Text PDFUltrasound-assisted immersion freezing improves the digestion properties of beef myofibrillar protein.
Food Chem X
January 2025
College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China.
This study focused on the effect of ultrasound-assisted immersion freezing (UIF) with different ultrasound power (200, 400, 600 W) on the physicochemical and digestive properties of beef myofibrillar proteins (BMP). The results showed that the solubility and thermal stability of BMP were significantly increased, when treated with 400 W ultrasound, and the α-helix, β-sheets, β-turns, and random-coil fractions structures content were higher and the fluorescence intensity was closest to that of the control group, demonstrating enhanced structural stability of BMP. The protein digestibility of the UIF-400 W group was significantly enhanced while the particle size of the digested product was reduced, which proved its enhanced digestion characteristics.
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