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| http://dx.doi.org/10.1016/j.bpj.2018.11.3125 | DOI Listing |
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Karyopherin-centric control of nuclear pores based on molecular occupancy and kinetic analysis of multivalent binding with FG nucleoporins.
Biophys J
April 2014
Biozentrum and the Swiss Nanoscience Institute, University of Basel, Basel, Switzerland. Electronic address:
Intrinsically disordered Phe-Gly nucleoporins (FG Nups) within nuclear pore complexes exert multivalent interactions with transport receptors (Karyopherins (Kaps)) that orchestrate nucleocytoplasmic transport. Current FG-centric views reason that selective Kap translocation is promoted by alterations in the barrier-like FG Nup conformations. However, the strong binding of Kaps with the FG Nups due to avidity contradicts rapid Kap translocation in vivo.
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