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Timely treatment of severe maternal hypertension and reduction in severe maternal morbidity. | LitMetric

Timely treatment of severe maternal hypertension and reduction in severe maternal morbidity.

Pregnancy Hypertens

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Published: October 2018

AI Article Synopsis

  • The study aimed to see if treating severe maternal hypertension within 60 minutes of diagnosis reduces severe maternal morbidity.
  • Researchers analyzed medical records of 465 women with severe hypertension, finding that 56% received timely treatment, leading to a lower rate of severe maternal morbidity (1.9%) compared to those who didn't (6.4%).
  • The conclusion suggested that timely antihypertensive treatment significantly decreases the risk of severe maternal complications and supports existing medical guidelines for treating severe hypertension quickly.

Article Abstract

Objective: To determine if timely treatment within 60 min of confirmed diagnosis of severe maternal hypertension with antihypertensive medications was associated with reduction in severe maternal morbidity.

Study Design: Medical records of women with severe hypertension (at least two severe blood pressures, systolic ≥160 mmHg and/or diastolic ≥110 mmHg, within 60 min) were accessed for timing of severe blood pressures, timing of treatment, and blood pressure response to treatment. Severe maternal morbidity was confirmed by multidisciplinary case review. We compared the incidence of severe maternal morbidity between women who received timely (within 60 min of diagnosis) vs. not-timely treatment.

Results: Of 465 women with severe hypertension, 29 (6.2%) experienced severe maternal morbidity. Fifty-six percent of women received timely treatment, of whom 1.9% had severe maternal morbidity, compared with 6.4% of women who did not receive timely treatment (p = 0.02). Timely treatment was associated with a 72% reduction in relative risk of severe maternal morbidity (p = 0.02). No significant difference was seen in median pre-treatment systolic pressures (p = 0.20) between the groups.

Conclusion: Antihypertensive treatment within 60 min of confirmed diagnosis of severe hypertension was associated with reduction in severe maternal morbidity. Our findings support current recommendations to treat all women with severe hypertension with antihypertensive medications in a timely fashion.

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Source
http://dx.doi.org/10.1016/j.preghy.2018.07.010DOI Listing

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