Acute monoblastic leukemia (AMoL) is a rare hematopoietic neoplasm, and simultaneous occurrence of acute monoblastic leukemia with chronic lymphocytic leukemia is very rare and only a few cases have been reported in the literature. We here report a rare case of dual hematological malignancy in an 85-year-old male. The peripheral blood and bone marrow examination revealed dual population of atypical cells, comprising large cells with opened-up chromatin having monocytic appearance and small mature-appearing lymphocytes. Flowcytometric immunophenotyping confirmed the monocytic lineage of cells, whereas small lymphocytes showed the immunophenotype consistent with chronic lymphocytic leukemia (CLL). The final diagnosis was made as acute monoblastic leukemia with associated CLL. This is a rare case scenario, and this highlights the importance of careful morphological examination and flowcytometric immunophenotyping in the exact characterization of hematopoietic malignancies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247670 | PMC |
| http://dx.doi.org/10.1155/2018/6452843 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bone-Marrow-Targeted Nanocomposite Abrogates C-Myb-Survivin Cross Talk in MLL-AF9-Rearranged Acute Myeloid Leukemia in and Patient-Derived Xenograft Models.
ACS Appl Mater Interfaces
December 2024
Epigenetics Research Laboratory, Institute of Nano Science and Technology, Knowledge City, Sector 81, Mohali, Punjab 140306, India.
The heterogeneous form of malignancy in the myeloid lineage of normal hematopoietic stem cells (HSCs) is characterized as acute myeloid leukemia (AML). The t(9;11) reciprocal translocation (p22;q23) generates MLL-AF9 oncogene, which results in myeloid-based monoblastic AML with frequent relapse and poor survival. MLL-AF9 binds with the C-Myb promoter and regulates AML onset, maintenance, and survival.
View Article and Find Full Text PDFComprehensive multi-omics analysis of the prognostic value and immune signature of NCF2 in pan-cancer and its relationship with acute myeloid leukemia.
Int Immunopharmacol
December 2024
Department of Pediatrics, Children Hematological Oncology and Birth Defects Laboratory, The Affiliated Hospital of Southwest Medical University, Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, PR China. Electronic address:
Background: The neutrophil cytoplasmic factor 2 (NCF2) gene encodes the p67phox protein, which has been implicated in the pathogenesis of several diseases. However, its specific role in tumorigenesis remains ambiguous. This study seeks to clarify the prognostic implications, immune profile, and therapeutic responses associated with NCF2 across different cancer types.
View Article and Find Full Text PDFCAE-ResVGG FusionNet: A Feature Extraction Framework Integrating Convolutional Autoencoders and Transfer Learning for Immature White Blood Cells in Acute Myeloid Leukemia.
Heliyon
October 2024
Dept of Hematology, Stem Cell Transplantation and Cellular Therapy, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
Article Synopsis
- Acute myeloid leukemia (AML) is a severe type of cancer affecting white blood cells, necessitating prompt diagnosis for effective treatment.
- The study introduces "CAE-ResVGG FusionNet," a computer-aided diagnostic system that uses advanced image processing techniques to accurately identify and classify immature white blood cells into four subtypes.
- The framework includes stages for data preprocessing, feature extraction, classification using ensemble methods, and performance validation to ensure high accuracy and reliability in diagnosing AML.
Growth hormone is involved in GATA1 gene expression via STAT5B in human erythroleukemia and monocytic cell lines.
Blood Cells Mol Dis
February 2025
Medicine & Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo 663-8179, Japan; Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan. Electronic address:
Article Synopsis
- GATAs are a transcription factor family with six members, where GATA1 and GATA2 are crucial for the development of specific blood cells like erythrocytes and eosinophils.
- The study explores whether growth hormone (GH) acts as an external stimulant for GATA1 expression in blood cell lines, employing various lab techniques to assess this relationship.
- Results indicate that GH enhances GATA1 expression through a pathway involving the GHR/JAK/STAT5 signaling mechanism, indicating its role in the proliferation of hematopoietic cells.
The Aryl Hydrocarbon Receptor Regulates Invasiveness and Motility in Acute Myeloid Leukemia Cells through Expressional Regulation of Non-Muscle Myosin Heavy Chain IIA.
Int J Mol Sci
July 2024
Department of Physiology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 110460, Republic of Korea.
Acute myeloid leukemia (AML) is the most prevalent type of hematopoietic malignancy. Despite recent therapeutic advancements, the high relapse rate associated with extramedullary involvement remains a challenging issue. Moreover, therapeutic targets that regulate the extramedullary infiltration of AML cells are still not fully elucidated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!