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Health and Experiences During the COVID-19 Pandemic Among Children and Young People: Analysis of Free-Text Responses From the Children and Young People With Long COVID Study.
J Med Internet Res
January 2025
Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London, United Kingdom.
Background: The literature is equivocal as to whether the predicted negative mental health impact of the COVID-19 pandemic came to fruition. Some quantitative studies report increased emotional problems and depression; others report improved mental health and well-being. Qualitative explorations reveal heterogeneity, with themes ranging from feelings of loss to growth and development.
View Article and Find Full Text PDFA Biomimetic Passive Mechanotransduction Mechanism Based on Interfacial Regulation of Ionic p-n Junctions.
ACS Nano
January 2025
School of Mechanical Engineering, Sichuan University, Chengdu 610065, China.
Natural skin receptors use ions as signal carriers, while most of the developed artificial tactile sensors utilize electrons as information carriers. To imitate the biological ionic sensing behavior, here, we present a kind of biomimetic, ionic, and fully passive mechanotransduction mechanism leveraging mechanical modulation of interfacial ionic p-n junction (IPNJ) through microchannels. Sensors based on this mechanism do not rely on an external power supply and can encode external tactile stimuli into highly analogous signal outputs to those of natural skin receptors, in terms of both signal type (i.
View Article and Find Full Text PDFPositive feedback regulation between RpoS and BosR in the Lyme disease pathogen.
mBio
January 2025
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
In , the causative agent of Lyme disease, differential gene expression is primarily governed by the alternative sigma factor RpoS (σ). Understanding the regulation of RpoS is crucial for elucidating how is maintained throughout its enzootic cycle. Our recent studies have shown that the homolog of Fur/PerR repressor/activator BosR functions as an RNA-binding protein that controls the mRNA stability.
View Article and Find Full Text PDFAutomatic classification of temporomandibular joint disorders by magnetic resonance imaging and convolutional neural networks.
J Dent Sci
January 2025
Institute of Statistics, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan.
Background/purpose: In this study, we utilized magnetic resonance imaging data of the temporomandibular joint, collected from the Division of Oral and Maxillofacial Surgery at Taipei Veterans General Hospital. Our research focuses on the classification and severity analysis of temporomandibular joint disease using convolutional neural networks.
Materials And Methods: In gray-scale image series, the most critical features often lie within the articular disc cartilage, situated at the junction of the temporal bone and the condyles.
Food supply toxicants and additives alter the gut microbiota and risk of metabolic disease.
Am J Physiol Endocrinol Metab
January 2025
Department of Biochemistry and Biomedical Sciences.
Metabolic disease is rising along with both global industrialization and the use of new commercial, agricultural, and industrial chemicals and food additives. Exposure to these compounds may contribute to aspects of metabolic disease such as obesity, diabetes, and fatty liver disease. Ingesting compounds in the food supply is a key route of human exposure, resulting in the interaction between toxicants or additives and the intestinal microbiota.
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