Background: The urinary tract infections are the third cause of infections in Mexico. The inappropriate use of antibiotic has generated the presence of multidrugresistant bacteria.
Objective: To identify the bacterial resistance patterns of the hospital and to detect the present comorbidities that can modify the evolution of urinary tract infection for proper empirical management.
Methods: Non-comparative cross-sectional study, positive urine cultures were reviewed in the period from December 2015 to May 2016, in outpatients of urology in the hospital. The obtained growth, bacterial resistance and the comorbidities of each patient were analyzed.
Results: 190 urine cultures were included. The most frequent bacterium was Escherichia coli. Greater general antibiotic resistance was detected to ceftazidime (91.5%), quinolones (> 65%) and trimethoprim / sulfamethoxazole (58%). The general multiresistance was 66.3%. The antibiotics that showed greater sensitivity were: amikacin, imipenem, nitrofurantoin, meropenem and piperacillin / tazobactam. The most frequent comorbidities were diabetes mellitus, previous use of antibiotics for urinary tract infection and prostatic hyperplasia.
Conclusion: In patients with urinary tract infection in the hospital, the empirical use of nitrofurantoin and amikacin is recommended. Quinolones and trimethoprim / sulfamethoxazole have a high resistance index.
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Front Biosci (Landmark Ed)
January 2025
Department of Zoology, College of Science, King Saud University, 11451 Riyadh, Saudi Arabia.
Background: We investigated chitosan's protective effects against tertiary butylhydroquinone (TBHQ)-induced toxicity in adult male rats, focusing on cognitive functions and oxidative stress in the brain, liver, and kidneys.
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Front Biosci (Landmark Ed)
January 2025
Department of Surgery, School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.
Sulfatides or 3-O-sulfogalactosylceramide are negatively charged sulfated glycosphingolipids abundant in the brain and kidneys and play crucial roles in nerve impulse conduction and urinary pH regulation. Sulfatides are present in the liver, specifically in the biliary tract. Sulfatides are self-lipid antigens presented by cholangiocytes to activate cluster of differentiation 1d (CD1d)-restricted type II natural killer T (NKT) cells.
View Article and Find Full Text PDFPlants (Basel)
January 2025
The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
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View Article and Find Full Text PDFNutrients
January 2025
Department of Biochemistry and Molecular Biology, School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao 266071, China.
A fucoidan oligosaccharide (FOS), a potent compound derived from algae, is known for its diverse biological activities, including prebiotic activity, anticancer activity, and antioxidative properties, and has demonstrated supportive therapeutic effects in treating kidney ailments. This study was conducted to explore the protective influence of FOS on kidney damage due to aging induced by D-galactose in Sprague Dawley (SD) rats. The low-dose FOS group was administered FOS (100 mg/kg) by gavage, and the high-FOS group received FOS (200 mg/kg) by gavage.
View Article and Find Full Text PDFNutrients
January 2025
Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Background/objectives: Chronic gut dysbiosis due to a high-fat diet (HFD) instigates cardiac remodeling and heart failure with preserved ejection fraction (HFpEF), in particular, kidney/volume-dependent HFpEF. Studies report that although mitochondrial ATP citrate lyase (ACLY) supports cardiac function, it decreases more in human HFpEF than HFrEF. Interestingly, ACLY synthesizes lipids and creates hyperlipidemia.
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