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Despite the sequencing revolution, large swaths of the genomes sequenced to date lack any information about the arrangement of transcription factor binding sites on regulatory DNA. Massively Parallel Reporter Assays (MPRAs) have the potential to dramatically accelerate our genomic annotations by making it possible to measure the gene expression levels driven by thousands of mutational variants of a regulatory region. However, the interpretation of such data often assumes that each base pair in a regulatory sequence contributes independently to gene expression.
View Article and Find Full Text PDFFrom thrombosis to tamponade: unveiling severe pericardial effusion in a misdiagnosis case.
Int J Emerg Med
January 2025
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Anticoagulants increase the risk of cardiac tamponade in patients with pericardial effusion (PE). Therefore, inappropriate administration of them in the presence of PE can lead to a catastrophic outcome. This study presents a patient with a provisional misdiagnosis of venous thromboembolism (VTE).
View Article and Find Full Text PDFInteracting Dark Energy after DESI Baryon Acoustic Oscillation Measurements.
Phys Rev Lett
December 2024
School of Mathematics and Statistics, University of Sheffield, Hounsfield Road, Sheffield S3 7RH, United Kingdom.
Article Synopsis
- The study examines how baryon acoustic oscillations data from the Dark Energy Spectroscopic Instrument affects interacting dark energy (IDE) models, which suggest an energy transfer between dark matter and dark energy.
- By integrating data from Planck-2018 and the Dark Energy Spectroscopic Instrument, researchers find a noticeable preference for interactions, leading to a present-day expansion rate that alleviates existing tensions with other measurements.
- Although the IDE model offers a compelling explanation for various observational data and presents compatible expansion rates, it does struggle with predictions related to the overall matter density and large-scale structures in the universe.
Biopotency of Avicennia marina leaf extracts against pathogenic bacteria in carp culture.
AMB Express
January 2025
Department of Zoology and Aquaculture, Acharya Nagarjuna University, Guntur, 522510, Andhra Pradesh, India.
Disease emergence has become a main limiting factor in aquaculture. The massive application of antibiotics as disease therapy has been resulting in the adverse effects of environment, host and consumers. Ethyl acetate leaf extract of A.
View Article and Find Full Text PDFA Focal Traumatic Injury to the Neonatal Rodent Spinal Cord Causes an Immediate and Massive Spreading Depolarization Sustained by Chloride Ions, with Transient Network Dysfunction.
Cell Mol Neurobiol
January 2025
Neuroscience Department, International School for Advanced Studies (SISSA), Via Bonomea 265, Trieste, TS, Italy.
In clinics, physical injuries to the spinal cord cause a temporary motor areflexia below lesion, known as spinal shock. This topic is still underexplored due to the lack of preclinical spinal cord injury (SCI) models that do not use anesthesia, which would affect spinal excitability. Our innovative design considered a custom-made micro impactor that provides localized and calibrated strikes to the ventral surface of the thoracic spinal cord of the entire CNS isolated from neonatal rats.
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