AI Article Synopsis
- Opioid misuse and dependence, a global issue, is addressed with Buprenorphine/naloxone (BNC), a drug that reduces opioid cravings and is safer than full agonists.
- BNC combines buprenorphine, a partial agonist, with naloxone, an antagonist that prevents misuse through intravenous diversion, making it suitable for detoxification and maintenance in opioid dependence.
- The article discusses a case of a monitored patient misusing BNC intravenously alongside oral pregabalin, which is also becoming known for its potential misuse.
Article Abstract
Opioid misuse and dependence are major medical and social concerns worldwide. Buprenorphine/naloxone combination (BNC) is a drug that has misuse potential and is used to treat opioid dependence, including buprenorphine and naloxone. Buprenorphine shows its pharmacological effects by binding to opioid receptors. Buprenorphine is a partial agonist and has smaller maximal effects compared to those of full agonists (heroin, methadone). Naloxone is a non-selective opiate antagonist added to buprenorphine for the prevention of intravenous diversion. BNC is used in the treatment of opioid dependence for detoxification and maintenance. The drug should be used as a sublingual film tablet. Pregabalin is used in the treatment of neuropathic pain, epilepsy and anxiety disorders. It is increasingly being reported as possessing a potential for misuse. In this article, we present a case of intravenous BNC and concomitant oral pregabalin misuse that developed in a monitored and treated patient for the reason of opioid dependence.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233699 | PMC |
| http://dx.doi.org/10.2147/NDT.S179688 | DOI Listing |
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