AI Article Synopsis
- Leishmaniasis, Chagas disease, and malaria are significant global health issues, and current treatments have limitations, prompting research into new compounds.
- Cinnamic acid analogs were tested for their effectiveness against specific protozoa, and their safety was assessed on NCTC 929 cells.
- Three of the tested analogs showed promising antiprotozoal effects, with no harmful side effects noted, indicating potential for further development in treating these diseases.
Article Abstract
Introduction: Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal compounds.
Methods: In vitro effects of analogs against L. braziliensis, L. infantum chagasi, T. cruzi, and P. falciparum, and hemolytic and cytotoxic activities on NCTC 929 were determined.
Results: Three analogs showed leishmanicidal and tripanocidal activity. No antiplasmodial, hemolytic, or cytotoxic activity was observed.
Conclusions: Antiprotozoal activity of analogs against L. infantum braziliensis, L. infantum chagasi, and T. cruzi was demonstrated.
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| http://dx.doi.org/10.1590/0037-8682-0499-2017 | DOI Listing |
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