CLINICAL-PATHOGENETICAL ROLE OF DYNAMICS OF CONCENTRATION OF INTERLEUKIN-6 DEPENDING ON POLYMORPHISM OF ITS GENE IN CONDUCTING ANTIVIRAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C.

The study included 83 patients with CHC who received antiviral therapy according to the EASL 2016 recommendations on a 12-week peg-IFN+SOF+RBV schedule. The aim of the study was to determine the role of IL-6 concentration dynamics in relation to the polymorphism of the gene that encodes it, in achieving a SVR during therapy. Based on the results of the study, it was established that the polymorphism of the IL-6 gene (rs1800795) in patients with CHC influenced the dynamics of IL-6 concentration and the effectiveness of AVT. In patients with CHC, the genotype CC of the polymorphism of the IL-6 gene was associated with fluctuations in the concentration of IL-6 in the blood within the reference range, which was prognostically favorable for the formation of SVR 24 for AVT according to the peg-IFNα + SOF + RBV. With the presence of CG/GG genotypes in patients with CHC, the efficacy of this treatment was lower than in patients with CC genotypes (85,5% vs. 100%). The ineffectiveness of AVT according to the scheme peg-IFNα+SOF+RBV was associated with the presence of CG/GG genotypes and the highest concentration of IL-6 in the blood.