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Biofabricated zinc oxide nanoparticles mitigate acrylamide-induced immune toxicity and modulate immune-related genes and microRNA in rats.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Histology and Cell Biology, Faculty of Medicine, Kafr Elsheikh University, Kafr Elsheikh, Egypt.
This study evaluated the potential efficacy of eco-friendly biofabricated zinc oxide nanoparticles (GS-ZnONP) (10 mg/kg b.wt) to reduce the impacts of long-term oral acrylamide (ALD) exposure (20 mg/kg b.wt) on the blood cells, immune components, splenic oxidative status, and expression of CD20, CD3, CD4, CD8, TNF-α, caspase-3, microRNA-181a-5p, and microRNA-125-5p in rats in a 60-day experiment.
View Article and Find Full Text PDFAcrylamide-induced hypothalamic-pituitary-gonadal axis disruption in rats: Androgenic protective roles of apigenin by restoring testicular steroidogenesis through upregulation of 17β-HSD, CYP11A1 and CYP17A1.
Food Chem Toxicol
December 2024
Pharmacology Department, National Research Centre, Giza, 12622, Egypt. Electronic address:
Acrylamide (ARL) exposure induces significant toxicity to the hypothalamic-pituitary-gonadal (HPG) axis, leading to detrimental effects on behavior, neuroendocrine functions, steroidogensis, oxidative stress, inflammation, hormonal balance, sperm quality, and histopathological integrity in rats. This study investigates the protective role of oral apigenin (API; 10 or 20 mg/kg/day for 28 days) against ARL-induced toxicity in the HPG axis of male Wistar rats. Behavioral assessments revealed that ARL exposure impaired motor coordination and balance, as evidenced by increased landing foot splay distance and gait score.
View Article and Find Full Text PDFClass I HLA Alleles Are Associated With an Increased Risk of Osimertinib-Induced Hypersensitivity.
J Allergy Clin Immunol Pract
January 2025
Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei, and Keelung, Taiwan; Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan; Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan; Department of Dermatology, Beijing Tsinghua Chang Gung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China; Department of Dermatology, Ruijin Hospital, School of Medicine, Shanghai Jiao-tong University, Shanghai, China; Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan. Electronic address:
Article Synopsis
- - Osimertinib is an effective lung cancer drug, but it can cause severe allergic reactions, especially in Asian patients, which can complicate treatment.
- - A study of 17 patients showed that the genetic marker HLA-B*51:02 was found in a high percentage of those experiencing severe allergic reactions (SJS/TEN), indicating a strong genetic predisposition.
- - The presence of HLA-B*51:02 also correlated with higher levels of a specific protein related to these reactions, suggesting that individuals with this genetic marker may be at risk for severe side effects when taking osimertinib.
Temperature-dependent yield stress and wall slip behaviour of thermoresponsive Pluronic F127 hydrogels.
RSC Adv
July 2024
Soft and Active Matter Group, Department of Physics and Center for Atomic, Molecular and Optical Sciences & Technologies (CAMOST), Indian Institute of Science Education and Research (IISER) Tirupati Yerpedu Tirupati 517619 Andhra Pradesh India
This study explores the temperature-dependent dynamic yield stress of a triblock thermoresponsive polymer, Pluronic F127, with chemical structure (PEO)(PPO)(PEO), during the sol-gel transition. The yield stress can be defined as static, dynamic, or elastic, depending on the experimental protocol. We examine the dynamic yield stress estimation for this study, which usually entails utilizing non-Newtonian models like the Herschel-Bulkley (HB) or Bingham models to extrapolate the flow curve (shear rate against shear stress).
View Article and Find Full Text PDFNear-Complete Response to Osimertinib for Advanced Non-Small-Cell Lung Cancer in a Pretreated Patient Bearing Rare Compound Exon 20 Mutation (S768I + V774M): A Case Report.
Int J Mol Sci
July 2024
Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Third-generation tyrosine kinase inhibitors are the first-line gold standard in treating advanced non-small-cell lung cancer bearing common mutations, but data documenting clinical efficacy in uncommon mutations are currently limited. In this paper, we describe the case of a patient bearing uncommon compound mutations in exon 20, who experienced a near-complete response to third-line Osimertinib, with metabolic complete response of pulmonary, nodal and ostheolytic lesions. This radiological assessment corresponded to an ECOG PS improvement (from three to one) and a substantial clinical benefit for the patients.
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