AI Article Synopsis
- Scientists are looking at how two types of cells compete for space, where one type has a special gene called the Ras oncogene that can cause cancer.
- They set up an experiment where these two kinds of cells start moving towards a free area and then bump into each other.
- The results show that the cells with the Ras oncogene push the normal cells out of the way because they are stronger when they come into contact.
Article Abstract
We study the competition for space between two cell lines that differ only in the expression of the Ras oncogene. The two cell populations are initially separated and set to migrate antagonistically towards an in-between stripe of free substrate. After contact, their interface moves towards the population of normal cells. We interpret the velocity and traction force data taken before and after contact thanks to a hydrodynamic description of collectively migrating cohesive cell sheets. The kinematics of cells, before and after contact, allows us to estimate the relative material parameters for both cell lines. As predicted by the model, the transformed cell population with larger collective stresses pushes the wild type cell population.
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| http://dx.doi.org/10.1039/c8sm01523f | DOI Listing |
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