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Pacemaker Pocket Erosion: A Critical Issue Requiring Immediate Attention.
Cureus
December 2024
Cardiology, Quillen College of Medicine, East Tennessee State University, Johnson City, USA.
Cardiac implantable electronic devices (CIEDs), including pacemakers, implantable cardiac defibrillators (ICD), and cardiac resynchronization therapy (CRT) devices, regulate heart rate and rhythm in patients with cardiac conditions. With an aging population, CIED-related complications, especially pacemaker pocket infections, are rising. Risk factors include frailty, older age, and superficial device fixation, while risk mitigation involves larger pocket sizes, submuscular fixation, and absorbable antibacterial envelopes.
View Article and Find Full Text PDFQuest for the ideal assessment of electrical ventricular dyssynchrony in cardiac resynchronization therapy.
J Mol Cell Cardiol Plus
March 2024
Department of Physiology and Cardiology, the Netherlands.
This paper reviews the literature on assessing electrical dyssynchrony for patient selection in cardiac resynchronization therapy (CRT). The guideline-recommended electrocardiographic (ECG) criteria for CRT are QRS duration and morphology, established through inclusion criteria in large CRT trials. However, both QRS duration and LBBB morphology have their shortcomings.
View Article and Find Full Text PDFIdentifying non-responders to cardiac resynchronization therapy in the non-left bundle branch block.
J Interv Card Electrophysiol
January 2025
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan.
Background: Non-response to cardiac resynchronization therapy (CRT) is an important issue in the treatment of heart failure with reduced ejection fraction (HFrEF) and non-left bundle branch block (LBBB). Electrocardiogram-gated myocardial perfusion single-photon emission computed tomography imaging (G-MPI SPECT) is typically used to assess left ventricular (LV) dyssynchrony. This study aimed to determine whether G-MPI parameters are associated with non-responsiveness to CRT.
View Article and Find Full Text PDFRefining cardiac resynchronization therapy: a comprehensive review on the role of advanced multimodality imaging.
Front Cardiovasc Med
December 2024
Department of Cardiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Cardiac resynchronization therapy (CRT) offers significant benefits in symptom alleviation, reduction of rehospitalization rates, and overall survival of patients with heart failure (HF) with reduced ejection fraction (rEF). However, despite its proven efficacy, precisely identifying suitable CRT candidates remains a challenge, with a notable proportion of patients experiencing non-response. Accordingly, many attempts have been made to enhance patient selection, and to identify the best imaging parameters to predict the response and survival after CRT implantation.
View Article and Find Full Text PDFThe Role of Cardiac Resynchronization Therapy in Heart Failure: A Narrative Review.
Health Sci Rep
January 2025
Department of Research and Education, Oli Health Magazine Organization Research and Education Kigali Rwanda.
Introduction: Structural and functional cardiac defects leading to inadequate tissue oxygenation is known as Heart failure (HF) which is characterized by extensive morbidity and mortality. Pathophysiology of HF involves systolic and diastolic dysfunction, neurohormonal dysregulation, and imbalance in inflammatory mediators which complicates treatment further. Cardiac resynchronization therapy (CRT) is an approach used for restoring ventricular synchrony and enhancing mechanical efficiency.
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