Background: Although the objective depression evaluation is a hot topic in recent years, less is known concerning developing a pervasive and objective approach for quantitatively evaluating depression. Driven by the Wisdom as a Service architecture, a quantitative analysis method for rating depressive mood status based on forehead electroencephalograph (EEG) and an electronic diary log application named quantitative log for mental state (Q-Log) is proposed. A regression method based on random forest algorithm is adopted to train the quantitative model, where independent variables are forehead EEG features and the dependent variables are the first principal component (FPC) values of the Q-Log.
Results: The Leave-One-Participant-Out Cross-Validation is adopted to estimate the performance of the quantitative model, and the result shows that the model outcomes have a moderate uphill relationship (the average coefficient equals 0.6556 and the P value less than 0.01) with the FPC values of the Q-Log. Furthermore, an exemplary application of knowledge sharing, which is developed by using ontology technology and Jena inference subsystem, is given to illustrate the preliminary work for annotating data and facilitating clinical users to understand the meaning of the quantitative analysis results.
Conclusions: This method combining physiological sensor data with psychological self-rating data could provide new insights into the pervasive and objective depression evaluation processes in daily life.
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http://dx.doi.org/10.1186/s40708-018-0093-y | DOI Listing |
Radiat Oncol
January 2025
German Cancer Consortium (DKTK), partner site Tübingen, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Background: For radiotherapy of head and neck cancer (HNC) magnetic resonance imaging (MRI) plays a pivotal role due to its high soft tissue contrast. Moreover, it offers the potential to acquire functional information through diffusion weighted imaging (DWI) with the potential to personalize treatment. The aim of this study was to acquire repetitive DWI during the course of online adaptive radiotherapy on an 1.
View Article and Find Full Text PDFHereditas
January 2025
Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education & Key Laboratory of Human Reproductive Medicine and Genetic Research of Hainan Provincie & Hainan Provincial Clinical Research Center for Thalassemia, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, 571101, China.
Background: The dynein cytoplasmic two heavy chain 1 (DYNC2H1) gene encodes a cytoplasmic dynein subunit. Cytoplasmic dyneins transport cargo towards the minus end of microtubules and are thus termed the "retrograde" cellular motor. Mutations in DYNC2H1 are the main causative mutations of short rib-thoracic dysplasia syndrome type III with or without polydactyly (SRTD3).
View Article and Find Full Text PDFCancer Imaging
January 2025
Melbourne Theranostic Innovation Centre, Level 8, 14-20 Blackwood St, North Melbourne, VIC, 3051, Australia.
True total-body and extended axial field-of-view (AFOV) PET/CT with 1m or more of body coverage are now commercially available and dramatically increase system sensitivity over conventional AFOV PET/CT. The Siemens Biograph Vision Quadra (Quadra), with an AFOV of 106cm, potentially allows use of significantly lower administered radiopharmaceuticals as well as reduced scan times. The aim of this study was to optimise acquisition protocols for routine clinical imaging with FDG on the Quadra the prioritisation of reduced activity given physical infrastructure constraints in our facility.
View Article and Find Full Text PDFBMC Pharmacol Toxicol
January 2025
Department of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Background: Glia mediated neuroinflammation and degeneration of inhibitory GABAergic interneurons are some of the hall marks of pyrethroid neurotoxicity. Here we investigated the sex specific responses of inflammatory cytokines, microglia, astrocyte and parvalbumin positive inhibitory GABAergic interneurons to λ-cyhalothrin (LCT) exposures in rats.
Methods: Equal numbers of male and female rats were given oral corn oil, 2 mg/kg.
BMC Health Serv Res
January 2025
Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Introduction: The COVID-19 pandemic forced leaders and employees in health care services to take difficult decisions to manage risks associated with employee health and the organizations' functioning. This study aims to identify the changes in employee working routines, job demands, and job resources within Swedish maternal healthcare during the COVID-19 pandemic, and how these changes affected workload and health.
Methods: Data were derived from the longitudinal COPE Staff study involving midwives and physicians within maternal healthcare.
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