AI Article Synopsis
- Direct pulp capping therapies utilize biomaterials to protect exposed dental tissues and promote healing, and this study aimed to evaluate their effectiveness through a systematic review and meta-analysis.
- The study analyzed literature from major databases, comparing the success rates of different biomaterials like mineral trioxide aggregate (MTA) and calcium hydroxide cements, as well as tricalcium silicate cements against each other.
- The results indicated that MTA cements had a significantly higher success rate compared to calcium hydroxide cements and lower inflammatory responses, while no notable differences were found between MTA and tricalcium silicate cements, and adhesive systems had the lowest rates of success.
Article Abstract
Introduction: Direct pulp capping therapies use biomaterials to protect exposed tissues, inducing repair through the production of a mineralized barrier. The purpose of this study was to compare the effectiveness of biomaterials and techniques by means of a systematic review and meta-analysis.
Methods: The PubMed, Cochrane, and Embase databases were used to search the literature published from January 1, 1980 until August 31, 2017. Studies that met inclusion criteria were screened by 2 authors individually. The meta-analysis was performed on mineral trioxide aggregate (MTA) cement vs calcium hydroxide cement, tricalcium silicate cement vs MTA cement, and adhesive systems vs CaOH cement and evaluated the success rate, inflammatory response, and dentin bridge formation.
Results: Forty-six studies were included in the systematic review, while 22 studies were included in the meta-analysis. There was no significant heterogeneity between the studies. MTA cements showed a significantly higher success rate, in all parameters, compared with calcium hydroxide cements (odds ratio = 2.72; 95% confidence interval [CI] = 1.90-3.90; P = 0.000). However, when compared with the tricalcium silicate cements, there were no statistically significant differences (odds ratio = 1.18; 95% CI = 0.53-2.65; P = 0.672). Adhesive systems showed a significantly lower success rate, in all parameters, compared with calcium hydroxide cements (odds ratio = 0.062; 95% CI = 0.024-0.157; P = 0.000).
Conclusions: MTA cements have a higher success rate, with a lower inflammatory response and a more predictable hard dentin barrier formation than calcium hydroxide cements. However, there were no differences, in these parameters, when MTA cement was compared with tricalcium silicate cements. Dental adhesives systems showed the lowest success rates.
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| http://dx.doi.org/10.1016/j.jebdp.2018.02.002 | DOI Listing |
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