Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Sarcomatous transformation of IDH-mutant astrocytoma matching to methylation class oligosarcoma following embolization, a case report.
Acta Neuropathol Commun
December 2024
Department of Pathology, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
The mesenchymal transformations of infiltrating gliomas are uncommon events. This is particularly true of IDH-mutant astrocytomas and oligodendrogliomas, in which mesenchymal transformation is exceedingly rare. oligosarcoma is a newly recognized methylation class (MC) that represents transformed 1p/19q co-deleted oligodendrogliomas, but recent studies indicate it may be non-specific.
View Article and Find Full Text PDFSolitary fibrous tumor of the central nervous system with epithelioid neuroendocrine "Transdedifferentiation": A case report and review of the literatures.
Neuropathology
December 2024
Department of Pathology and Laboratory Medicine, UT Health-McGovern Medical School, Houston, Texas, USA.
Solitary fibrous tumors (SFTs) of the central nervous system (CNS) are rare mesenchymal tumors characterized by a fusion of the NGFI-A-binding protein 2 (NAB2) gene and the signal transducer and activator of transcription 6 (STAT6) gene, immunohistochemically resulting in nuclear expression of STAT6 - an immunohistochemical hallmark essential for diagnosis, as outlined in the fifth edition of the World Health Organization Classification of Tumors. Dedifferentiation, where low-grade tumors transform into high-grade forms, has been observed in SFTs, with documented cases involving sarcomatous or rarely epithelial transformations. We report the first case of a CNS SFT exhibiting "transdedifferentiation" into epithelioid neuroendocrine differentiation.
View Article and Find Full Text PDFUndifferentiated spindle cell sarcoma at the anastomosis after ileocecal resection for colon cancer: A case report.
Int J Surg Case Rep
December 2024
Department of Gastroenterological Surgery, National Hospital Organization Higashihiroshima Medical Center, 739-0041, 513, Jike, Saijocho, Higashihiroshima, Hiroshima, Japan.
Introduction: Spindle cell sarcoma (SCS) is a sarcoma subtype rarely described in the abdominal cavity, and with a worse prognosis compared with that at other sites. We report a case of SCS occurring at the anastomosis after ileal resection for colorectal cancer.
Presentation Of Case: An 86-year-old woman with a chief complaint of abdominal pain had undergone ileal resection, D2 dissection, and hand-sewn anastomosis in 2011 to treat papillary stage I adenocarcinoma.
Longitudinal multimodal profiling of IDH-wildtype glioblastoma reveals the molecular evolution and cellular phenotypes underlying prognostically different treatment responses.
Neuro Oncol
November 2024
UCSF Brain Tumor Center, University of California, San Francisco, California, USA.
Background: Despite recent advances in the biology of IDH-wildtype glioblastoma, it remains a devastating disease with median survival of less than 2 years. However, the molecular underpinnings of the heterogeneous response to the current standard-of-care treatment regimen consisting of maximal safe resection, adjuvant radiation, and chemotherapy with temozolomide remain unknown.
Methods: Comprehensive histopathologic, genomic, and epigenomic evaluation of paired initial and recurrent glioblastoma specimens from 106 patients was performed to investigate the molecular evolution and cellular phenotypes underlying differential treatment responses.
A Case of Pediatric Mixed Epithelial and Stromal Tumor of the Kidney With Atypical Stromal Cells.
Cureus
October 2024
Department of Diagnostic Pathology, Kobe University Hospital, Kobe, JPN.
Mixed epithelial and stromal tumor of the kidney (MESTK) is a rare renal tumor characterized by both cystic and solid components. Although typically benign, its components can undergo malignant transformation, manifesting as a sarcomatous feature. Carcinomatous transformations are exceedingly rare.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!