Driving and vision disorders. Optimal vision is mandatory for safe driving. Many either acute or chronic ophthalmological conditions may unconsciously alter the driver's vision. A sufficient visual function is mandatory to obtain a driver's license, with specific criteria depending on the type of the vehicle and the drivers's occupation. The Decree of 18 December 2015 amending the Decree of 21 December 2005 sets out a list of medical conditions incompatible with a driving license or which may lead to the issuance of driving licenses for a limited period of validity. Every driver must constantly be in both condition and position to perform all the required maneuvers without delay. The occurrence of different ophthalmological conditions throughout life is a key parameter to be considered when improving road safety. The regulation is clear about the procedures to be followed by the drivers but progress is still needed to inform patients about their disability and also the risks incurred by those suffering from ocular diseases. New generation driving simulators and the development of autonomous cars may improve road safety without limiting the autonomy even if the use is only scheduled for 2030.
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PLoS One
January 2025
School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR.
To investigate the pattern and threshold of physiological growth, defining as axial length (AL) elongation that results in little refraction progression, among Chinese children and teenagers, a total of 916 children aged between 7 and 18 years from a 6-year longitudinal cohort study were included for analysis. Ocular biometry, cycloplegic refraction and demographic data were obtained annually. Physiological growth was calculated based on myopic progression and Gullstrand eye model, respectively.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Medical and Surgical Sciences and Advanced Technologies "G. F. Ingrassia", University of Catania, Catania, Italy.
Background: To date, few data to transcranial Doppler sonography (TCD) are available in patients with mild vascular cognitive impairment (VCI) at risk for vascular or mixed dementia. In a previous study in patients with mild VCI and cerebral small vessels disease, a hemodynamic pattern of cerebral hypoperfusion and enhanced vascular resistance were observed; however, longitudinal data are currently lacking. Here, we perform a clinical, psychopathological, and neurosonological follow-up of patients with VCI in order to monitor any progression and to identify TCD measures to detect it.
View Article and Find Full Text PDFTransl Vis Sci Technol
January 2025
Glaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA.
Purpose: The integration of artificial intelligence (AI), particularly deep learning (DL), with optical coherence tomography (OCT) offers significant opportunities in the diagnosis and management of glaucoma. This article explores the application of various DL models in enhancing OCT capabilities and addresses the challenges associated with their clinical implementation.
Methods: A review of articles utilizing DL models was conducted, including convolutional neural networks (CNNs), recurrent neural networks (RNNs), generative adversarial networks (GANs), autoencoders, and large language models (LLMs).
Transl Vis Sci Technol
January 2025
UCL Institute of Ophthalmology, University College London, London, UK.
Purpose: A human model able to simulate the manifestation of corneal endothelium decompensation could be advantageous for wound healing and future cell therapy assessment. The study aimed to establish an ex vivo human cornea endothelium wound model where endothelium function can be evaluated by measuring corneal thickness changes.
Methods: The human cornea was maintained in an artificial anterior chamber, with a continuous culture medium infusion system designed to sustain corneal endothelium and epithelium simultaneously.
Curr Eye Res
January 2025
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
Purpose: This study aims to conduct a mini review of published literature concerning the role of exosomes in the field of ophthalmology, with a specific focus on Age-Related Macular Degeneration (AMD).
Methods: In this study, a comprehensive search was conducted using PubMed and Google Scholar to identify relevant publications. Additionally, trials submitted to clinicaltrials.
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