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Vitamin D protects spermatogonia and Sertoli cells from heat stress damage by inhibiting NLRP3.
Front Pediatr
January 2025
Pathology Department, Anhui Provincial Children's Hospital, Hefei, Anhui, China.
Introduction: Cryptorchidism can damage cells in the cryptorchid testes due to elevated local temperatures, potentially impacting the fertility of the child in adulthood. Research indicates that vitamin D enhances sperm quality in adult males. This study aimed to explore whether vitamin D inhibits NLRP3 activation, thus helping to mitigate heat stress damage to testicular spermatogenic and Sertoli cells.
View Article and Find Full Text PDFA Case of Severe Lupus and Refractory Anemia.
Cureus
December 2024
Internal Medicine, Hospital da Senhora da Oliveira, Guimarães, PRT.
Systemic lupus erythematosus (SLE) is a multisystemic connective tissue disease with a wide range of clinical and laboratory manifestations. The diagnosis of SLE is often challenging due to the great variability in its presentation, and treatment should be individualized according to the patient's manifestations and affected organs. We present the clinical case of a 25-year-old female who developed SLE with severe hematological and renal involvement as first manifestations, including hemolytic anemia, thrombocytopenia, and nephrotic syndrome.
View Article and Find Full Text PDFReassessing the hypothesis of essential tremor as a prodromal feature of Parkinson's disease.
Parkinsonism Relat Disord
January 2025
Department of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China. Electronic address:
Insomnia in Patients With Substance Use Disorders: Assessment and Management.
J Psychiatr Pract
January 2025
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA.
Insomnia, characterized by difficulty initiating or maintaining sleep, or poor sleep quality, is highly prevalent among individuals with substance use disorders (SUDs). The relationship between the 2 conditions is often bidirectional. We reviewed the impact of various substances (alcohol, stimulants, opioids, and cannabis) on sleep architecture and their potential to contribute to insomnia.
View Article and Find Full Text PDFModel compression for real-time object detection using rigorous gradation pruning.
iScience
January 2025
Faculty of Engineering, Technology and Built Environment, UCSI University, Kuala Lumpur, Malaysia.
Achieving lightweight real-time object detection necessitates balancing model compression with detection accuracy, a difficulty exacerbated by low redundancy and uneven contributions from convolutional layers. As an alternative to traditional methods, we propose Rigorous Gradation Pruning (RGP), which uses a desensitized first-order Taylor approximation to assess filter importance, enabling precise pruning of redundant kernels. This approach includes the iterative reassessment of layer significance to protect essential layers, ensuring effective detection performance.
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