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Ratiometric fluorescent probe and smartphone-based visual recognition for HO and organophosphorus pesticide based on Ce/Ce cascade enzyme reaction.
Food Chem
December 2024
Laboratory of Functional Polymers, School of Materials Science and Engineering, Linyi University, Linyi 276005, China. Electronic address:
Organicphosphorus is a ubiquitous pesticide that has potential hazards to human health and environmental well-being. Therefore, the precise identification of residues of organophosphorus pesticides (OPs) emerges as an urgent necessity. A ratiometric fluorescent sensor for the detection of OPs by leveraging the catalytic activities of Ce and Ce on the two fluorescent substrates 4-Methylumbelliferyl phosphate (4-MUP) and o-phenylenediamine (OPD) correspondingly was designed.
View Article and Find Full Text PDFAssessment of Emphysema on X-ray Equivalent Dose Photon-Counting Detector CT: Evaluation of Visual Scoring and Automated Quantification Algorithms.
Invest Radiol
October 2024
From the Institute for Diagnostic and Interventional Radiology, University Hospital Zurich, University Zurich, Zurich, Switzerland (B.K., F.E., J.K., T.F., L.J.); Advanced Radiology Center, Department of Diagnostic Imaging and Oncological Radiotherapy, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy (C.S., A.R.L.); and Section of Radiology, Department of Radiological and Hematological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy (A.R.L.).
Objectives: The aim of this study was to evaluate the feasibility and efficacy of visual scoring, low-attenuation volume (LAV), and deep learning methods for estimating emphysema extent in x-ray dose photon-counting detector computed tomography (PCD-CT), aiming to explore future dose reduction potentials.
Methods: One hundred one prospectively enrolled patients underwent noncontrast low- and chest x-ray dose CT scans in the same study using PCD-CT. Overall image quality, sharpness, and noise, as well as visual emphysema pattern (no, trace, mild, moderate, confluent, and advanced destructive emphysema; as defined by the Fleischner Society), were independently assessed by 2 experienced radiologists for low- and x-ray dose images, followed by an expert consensus read.
Multiple attention channels aggregated network for multimodal medical image fusion.
Med Phys
December 2024
School of Physics and Optoelectronic Engineering, Foshan University, Foshan, China.
Background: In clinical practices, doctors usually need to synthesize several single-modality medical images for diagnosis, which is a time-consuming and costly process. With this background, multimodal medical image fusion (MMIF) techniques have emerged to synthesize medical images of different modalities, providing a comprehensive and objective interpretation of the lesion.
Purpose: Although existing MMIF approaches have shown promising results, they often overlook the importance of multiscale feature diversity and attention interaction, which are essential for superior visual outcomes.
Klebsiella pneumoniae Glycoconjugate Vaccine Leads Based on Semi-Synthetic O1 and O2ac Antigens.
Angew Chem Int Ed Engl
December 2024
Max Planck Institute of Colloids and Interfaces, Biomolecular Systems, Am Mühlenberg 1, Research Campus Golm, 14476, Potsdam, GERMANY.
Klebsiella pneumoniae (KP) is a common opportunistic pathogen that emerged as a new critical threat to human health, due to its hypervirulence and widespread resistance against many antibiotics, including carbapenems. Alternative intervention strategies such as vaccines are not available. Cell-surface lipopolysaccharides (LPS) and capsular polysaccharides (CPS) are attractive targets for vaccine development.
View Article and Find Full Text PDFDiagnostic and Therapeutic Approach to the Major Secondary Causes of Arterial Hypertension in Young Adults: A Narrative Review.
Cardiol Rev
October 2024
Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA.
Arterial hypertension in young adults, which includes patients between 19 and 40 years of age, has been increasing in recent years and is associated with a significantly higher risk of target organ damage and short-term mortality. It has been reported that up to 10% of these cases are due to a potentially reversible secondary cause, mainly of endocrine (primary aldosteronism, Cushing's syndrome, and pheochromocytoma/paraganglioma), renal (renovascular hypertension due to fibromuscular dysplasia and renal parenchymal disease), or cardiac (coarctation of the aorta) origin. It is recommended to rule out a secondary cause of high blood pressure (BP) in those patients with early onset of grade 2 or 3 hypertension, acute worsening of previously controlled hypertension, resistant hypertension, hypertensive emergency, severe target organ damage disproportionate to the grade of hypertension, or in the face of clinical or biochemical characteristics suggestive of a secondary cause of hypertension.
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