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What's the Leading Point? A Benign Polypoid Mass Behind the Trouble.
Kans J Med
September 2024
Gastroenterology Fellowship Program, University of Kansas School of Medicine-Wichita, Wichita, KS.
Evaluating metagenomic analyses for undercharacterized environments: what's needed to light up the microbial dark matter?
bioRxiv
November 2024
Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Non-human-associated microbial communities play important biological roles, but they remain less understood than human-associated communities. Here, we assess the impact of key environmental sample properties on a variety of state-of-the-art metagenomic analysis methods. In simulated datasets, all methods performed similarly at high taxonomic ranks, but newer marker-based methods incorporating metagenomic assembled genomes outperformed others at lower taxonomic levels.
View Article and Find Full Text PDFFlavokawain A suppresses the malignant progression of neuroblastoma in vitro depending on inactivation of ERK/VEGF/MMPs signaling pathway.
Discov Oncol
November 2024
Department of Pediatric Surgery, The Affiliated Taian City Central Hospital of Qingdao University, No.29 Longtan Road, Taishan District, Taian, 271000, Shandong Province, People's Republic of China.
Background: Neuroblastoma (NB), the most common extracranial solid tumor in children, is featured by high malignancy and poor prognosis. Flavokawain A (FKA), a novel chalcone isolated from the roots of the kava plant, has been identified to exert the tumor-inhibiting properties in various cancers. The present study was formulated to tell about the anticarcinogenic effects of FKA against NB and to thoroughly elucidate the intrinsic molecular mechanisms.
View Article and Find Full Text PDFSolid pancreatic masses: What's hidden beneath? Insights into rare pancreatic lesions.
World J Clin Cases
October 2024
Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania.
Article Synopsis
- The diagnostic techniques for solid pancreatic masses have improved, moving away from the assumption that all focal masses are pancreatic ductal adenocarcinoma to recognizing a variety of pancreatic lesions.
- Advanced imaging and tissue sampling methods now allow for the identification of different conditions, including neuroendocrine tumors and rare types like metastatic clear cell sarcoma.
- The article discusses case reports of rare pancreatic tumors diagnosed through a combination of clinical features, imaging, and endoscopic ultrasound-guided sampling, aiming to enhance understanding and management of these conditions.
The pharmacological management of alcohol-related cirrhosis: what's new?
Expert Opin Pharmacother
October 2024
Department of Medicine, Division of Gastroenterology and Hepatology, University of Louisville School of Medicine, Louisville, KY, USA.
Introduction: Alcohol use disorder (AUD) is present in the majority of patients with alcohol-associated liver disease (ALD), which leads to about 50% of cirrhosis-related hospitalizations and over 25% of deaths worldwide. Patients with ALD often present at an advanced stage, like cirrhosis with its complications and alcohol-associated hepatitis (AH), which has high short-term mortality. Current treatments are limited, with the limited benefit of glucocorticoids only in the short-term among patients with AH, highlighting an urgent need for novel therapies.
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