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Longer Total Interhospital Transfer Times for Rural Sepsis Patients Not Associated with Increased Mortality.
Prehosp Emerg Care
January 2025
Department of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Objectives: Sepsis is a time-sensitive condition, and many rural emergency department (ED) sepsis patients are transferred to tertiary hospitals. The objective of this study was to determine whether longer transport times during interhospital transfer are associated with higher sepsis mortality or increased hospital length-of-stay (LOS).
Methods: A cohort of rural adult (age ≥ 18y) sepsis patients transferred between hospitals were identified in the TELEmedicine as a Virtual Intervention for Sepsis Care in Emergency Departments (TELEVISED) parent study.
Sepsis: A Summary of the SEP-1 Quality Measure and Future Considerations.
Clin Microbiol Infect
December 2024
Department of Internal Medicine, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE. Electronic address:
Association between time to antibiotic and mortality in patients with suspected sepsis in the Emergency Department: post hoc analysis of the 1-BED randomized clinical trial.
Eur J Emerg Med
December 2024
Sorbonne Université, IMProving Emergency Care (IMPEC) FHU Paris.
Article Synopsis
- The study investigates the effect of early antibiotic administration on 28-day in-hospital mortality in patients with suspected sepsis in the emergency department.
- Among 872 participants, those who received antibiotics within an hour had a significantly lower mortality rate (9.6%) compared to those who received them later (14.7%).
- Delays in antibiotic treatment were linked to increased mortality risk, with an adjusted odds ratio of 2.00 for those who received antibiotics after one hour and a 1.06 increase in risk for each additional hour of delay.
Large Language Models for More Efficient Reporting of Hospital Quality Measures.
NEJM AI
October 2024
Division of Biomedical Informatics, University of California, San Diego, San Diego.
Hospital quality measures are a vital component of a learning health system, yet they can be costly to report, statistically underpowered, and inconsistent due to poor interrater reliability. Large language models (LLMs) have recently demonstrated impressive performance on health care-related tasks and offer a promising way to provide accurate abstraction of complete charts at scale. To evaluate this approach, we deployed an LLM-based system that ingests Fast Healthcare Interoperability Resources data and outputs a completed Severe Sepsis and Septic Shock Management Bundle (SEP-1) abstraction.
View Article and Find Full Text PDFPlanning a Phased Guideline Implementation Strategy Across the Multicenter Ventilation Liberation for Kids (VentLib4Kids) Collaborative.
Pediatr Crit Care Med
December 2024
Division of Pediatric Critical Care, Department of Pediatrics, Riley Hospital for Children at Indiana, University Health and Indiana University School of Medicine, Indianapolis, IN.
Article Synopsis
- The study aimed to assess factors affecting the implementation of ventilator liberation guidelines for pediatric patients and create a strategy for an international collaborative effort called VentLib4Kids.
- The survey involved 26 pediatric intensive care units (PICUs) across 18 centers, gathering 409 responses from various healthcare professionals, such as doctors, nurses, and respiratory therapists.
- Three implementation tiers were established based on consensus about various practices, showing that extubation readiness testing was well-agreed upon, while more complex practices like respiratory muscle strength testing had significant gaps in perception and agreement among respondents.
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