SYCP2 expression is a novel prognostic biomarker in luminal A/B breast cancer.

Aim: To explore the prognostic value of synaptonemal complex protein-2 (SYCP2) in different subtypes of breast cancer. Patients & materials: In silico bioinformatic analysis was conducted using large databases.

Results: SYCP2 was only significantly upregulated in luminal B tumors compared with the adjacent normal tissues. SYCP2 expression was an independent indicator of shorter overall survival in luminal A patients (hazard ratio: 2.269; 95% CI: 1.059-4.862; p = 0.035) and luminal B patients (hazard ratio: 2.546; 95% CI: 1.020-6.355; p = 0.045). Its expression was negatively correlated with the methylation status of multiple CpG sites (cg22214414, cg23241473 and cg07347645) in both luminal A and luminal B tumors.

Conclusion: Increased SYCP2 expression might be an independent indicator of shorter overall survival in both luminal A and luminal B patients.