There are several methods to encourage bilateral and multidisciplinary collaborations-the most oft-used and effective include technical conferences, workshops, and seminars with the optimal combination of people, agenda, and length. However, this balance is difficult to attain, especially for meetings across academic disciplines and geographic borders. For nearly two decades, the US National Academies have developed a series of bilateral meetings to bring together scientists in different countries, which appear to have addressed such challenges via concise meetings with select emerging leaders from disparate fields and sectors. The authors utilized a similar approach to promote US and Czech collaborations in nanotechnology, given their mutual investments in the area and interests in building relationships. The bilateral meeting was held in Prague and designed to focus on nanotechnology and chemistry. The goals were four-fold: (1) evaluate US and Czech capabilities and challenges in nanotechnology and chemistry, (2) identify likely research projects and funding sources for collaborations, (3) celebrate 100 years of US and Czech diplomatic relations, and (4) increase government and public support for bilateral scientific research. The two-day meeting was named the US-Czech Conference on Advanced Nanotechnology and Chemistry. A summary of the research presentations, funding opportunities, panel discussions, and potential joint projects are given herein. It is our hope that this perspective will facilitate similar bilateral meetings in other fields to promote more multidisciplinary research.
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http://dx.doi.org/10.1088/1361-6528/aaefb9 | DOI Listing |
J Mater Chem B
January 2025
Department of Advanced Materials Science & Engineering, Hanseo University, Seosan, Chungnam 31962, Republic of Korea.
MXenes are a class of 2D transition metal carbides and nitrides (MXT) that have attracted significant interest owing to their remarkable potential in various fields. The unique combination of their excellent electromagnetic, optical, mechanical, and physical properties have extended their applications to the biological realm as well. In particular, their ultra-thin layered structure holds specific promise for diverse biomedical applications.
View Article and Find Full Text PDFMol Cancer
January 2025
i3S - Instituto de Investigação e Inovação em Saúde, Universidade Do Porto, Rua Alfredo Allen 208, Porto, 4200‑135, Portugal.
Rectal cancer accounts for over 35% of the worldwide colorectal cancer burden representing a distinctive subset of cancers from those arising in the colon. Colorectal cancers exhibit a continuum of traits that differ with their location in the large intestine. Due to anatomical and molecular differences, rectal cancer is treated differently from colon cancer, with neoadjuvant chemoradiotherapy playing a pivotal role in the control of the locally advanced disease.
View Article and Find Full Text PDFNat Protoc
January 2025
Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv-Yafo, Israel.
Nanostructured devices have proven useful in a broad range of applications, from diagnosing diseases to discovering and screening new drug molecules. We developed vertical silicon nanopillar (SiNP) arrays for on-chip multiplex capture of selected biomolecules using a light-induced release of the array's selectively captured biomarkers. This platform allows the rapid, reusable and quantitative capture and release of a selection of biomarkers, followed by their downstream analysis.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Chemistry, Iran University of Science and Technology (IUST), Tehran, 1684613114, Iran.
This paper describes the design, development, synthesis, in silico, and in vitro evaluation of fourteen novel heterocycle hybrids as inhibitors of the α-glucosidase enzyme. The primary aim of this study was to explore the potential of novel pyrazole-phthalazine hybrids as selective inhibitors of α-glucosidase, an enzyme involved in carbohydrate metabolism, which plays a key role in the management of type 2 diabetes. The rationale for this study stems from the need for new, more effective inhibitors of α-glucosidase with improved efficacy and safety profiles compared to currently available therapies like Acarbose.
View Article and Find Full Text PDFNPJ Vaccines
January 2025
Department of Biochemistry, University of Oxford, OX1 3QU, Oxford, UK.
The rapid development and worldwide distribution of COVID-19 vaccines is a remarkable achievement of biomedical research and logistical implementation. However, these developments are associated with the risk of a surge of substandard and falsified (SF) vaccines, as illustrated by the 184 incidents with SF and diverted COVID-19 vaccines which have been reported during the pandemic in 48 countries, with a paucity of methods for their detection in supply chains. In this context, matrix-assisted laser desorption ionisation-time of flight (MALDI-ToF) mass spectrometry (MS) is globally available for fast and accurate analysis of bacteria in patient samples, offering a potentially accessible solution to identify SF vaccines.
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