antiprotozoal activity of some medicinal plants against sleeping sickness, Chagas disease and leishmaniasis.

Future Med Chem

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street, Cairo, 11562, Egypt.

Published: November 2018

Antiprotozoal activity of 36 medicinal plants was evaluated. potency against , , and beside cytotoxicity on MRC-5 fibroblasts were determined. showed the highest activity against (IC of 0.6 μg/ml) and (IC of 0.5 μg/ml) with low cytotoxicity (CC of 30 μg/ml). and , showed pronounced potency against with an IC of 3.6 and 2.5 μg/ml, respectively. and exhibited pronounced activity toward with an IC of 3.2 and 2.0 μg/ml, respectively. , c, , and showed relevant selectivity.

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http://dx.doi.org/10.4155/fmc-2018-0180DOI Listing

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