AI Article Synopsis
- - The study aimed to assess the safety and effectiveness of surgical left atrial appendage occlusion (s-LAAO) during heart surgeries, comparing it with cases where no occlusion was performed.
- - A thorough analysis of 12 studies involving over 40,000 patients revealed that s-LAAO significantly reduced the risk of embolic events and strokes, particularly in patients with a history of atrial fibrillation (AF).
- - The findings concluded that while s-LAAO during cardiac surgery lowers the likelihood of thromboembolic complications and strokes, it did not increase the rates of mortality or other adverse events, suggesting further research is needed to confirm long-term benefits.
Article Abstract
Aim: To evaluate the safety and efficacy of surgical left atrial appendage occlusion (s-LAAO) during concomitant cardiac surgery.
Methods: We performed a comprehensive literature search through May 31st 2018 for all eligible studies comparing s-LAAO vs no occlusion in patients undergoing cardiac surgery. Clinical outcomes during follow-up included: embolic events, stroke, all-cause mortality, atrial fibrillation (AF), reoperation for bleeding and postoperative complications. We further stratified the analysis based on propensity matched studies and AF predominance.
Results: Twelve studies (n = 40107) met the inclusion criteria. s-LAAO was associated with lower risk of embolic events (OR: 0.63, 95%CI: 0.53-0.76; P < 0.001) and stroke (OR: 0.68, 95%CI: 0.57-0.82; P < 0.0001). Stratified analysis demonstrated this association was more prominent in the AF predominant strata. There was no significant difference in the incidence risk of all-cause mortality, AF, and reoperation for bleeding and postoperative complications.
Conclusion: Concomitant s-LAAO during cardiac surgery was associated with lower risk of follow-up thromboembolic events and stroke, especially in those with AF without significant increase in adverse events. Further randomized trials to evaluate long-term benefits of s-LAAO are warranted.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259031 | PMC |
| http://dx.doi.org/10.4330/wjc.v10.i11.242 | DOI Listing |
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