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Coronin1A regulates the trafficking of alpha synuclein in microglia.
J Neurosci
January 2025
Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03766, USA.
Microglia respond to cytotoxic protein aggregates associated with the progression of neurodegenerative disease. Pathological protein aggregates activate the microglial NLRP3 inflammasome resulting in proinflammatory signaling, secretion, and potentially pyroptotic cell death. We characterized mixed sex primary mouse microglia exposed to microbial stressors and alpha synuclein preformed fibrils (αsyn PFFs) to identify cellular mechanisms related to Parkinson's disease.
View Article and Find Full Text PDFRewards transiently and automatically enhance sustained attention.
J Exp Psychol Gen
January 2025
Department of Psychology, Yale University.
Our ability to maintain a consistent attentional state is essential to many aspects of daily life. Still, despite our best efforts, attention naturally fluctuates between more and less vigilant states. Previous work has shown that offering performance-based rewards or incentives can help to buffer against attentional lapses.
View Article and Find Full Text PDFRegistered Nurses' Experience of Person-Centred Care Through Digital Aids in Primary Care Setting During the COVID-19 Pandemic.
Nurs Open
January 2025
Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden.
Aim: The aim of this study was to describe registered nurses' experience of person-centred care through digital media during the COVID-19 pandemic. The first wave of COVID-19 took healthcare services worldwide by surprise and affected all levels of care. Registered nurses within primary care settings had to adjust to new meeting forums with patients and in collaborations with other organisations to transfer patients from hospital to home care in a safe and secure manner using digital aids.
View Article and Find Full Text PDFThe SARS-CoV-2 nucleocapsid protein interferes with the full enzymatic activation of UPF1 and its interaction with UPF2.
Nucleic Acids Res
January 2025
Molecular Microbiology and Structural Biochemistry, MMSB-IBCP, CNRS UMR 5086 , Université Claude Bernard Lyon 1, F-69367 Lyon, France.
The nonsense-mediated mRNA decay (NMD) pathway triggers the degradation of defective mRNAs and governs the expression of mRNAs with specific characteristics. Current understanding indicates that NMD is often significantly suppressed during viral infections to protect the viral genome. In numerous viruses, this inhibition is achieved through direct or indirect interference with the RNA helicase UPF1, thereby promoting viral replication and enhancing pathogenesis.
View Article and Find Full Text PDFRelapsing ANCA-associated vasculitis presenting as a mediastinal mass.
BMJ Case Rep
January 2025
Department of Nephrology, Barts Health NHS Trust, London, UK.
Anti-neutrophil cytoplasmic antibody-associated vasculitides (AAV) represent a heterogeneous multisystem group of disorders typified by necrotising inflammation of smaller blood vessels, classically yielding a pauci-immune, crescentic glomerulonephritis. Without prompt treatment, there is a significant risk of irreversible damage and ensuing renal impairment.Diagnosis is often challenging, exacerbated by the disorder's often vague and insidious presentation.
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